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Recombinant Human OSBP1 protein (ab152583)

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SDS-PAGE - Recombinant Human OSBP1 protein (ab152583)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: SDS-PAGE, ELISA, WB

    製品の詳細

    • 製品名

      Recombinant Human OSBP1 protein

    • 発現系

      Wheat germ

    • アクセッション番号

      P22059

    • タンパク質長

      Protein fragment

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        GATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLG HKRTGSNISGASSDISLDEQYKHQLEETKKEKRT

      • 予測される分子量

        35 kDa including tags

      • 領域

        324 to 407

    特性

    Our Abpromise guarantee covers the use of ab152583 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      SDS-PAGE

      ELISA

      Western blot

    • 製品の状態

      Liquid
    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    関連情報

    • 別名

      • OSBP
      • OSBP 1
      • OSBP1_HUMAN
      • Oxysterol binding protein 1
      • Oxysterol-binding protein 1
      see all

    • 機能

      Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.

    • 組織特異性

      Widely expressed.

    • 配列類似性

      Belongs to the OSBP family.
      Contains 1 PH domain.

    • ドメイン

      The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
      The second coiled-coil domain is required for interaction with the tyrosine phosphatase.

    • 細胞内局在

      Cytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human OSBP1 protein (ab152583)
      SDS-PAGE - Recombinant Human OSBP1 protein (ab152583)
      12.5% SDS-PAGE analysis of ab152583 stained with Coomassie Blue.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab152583 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab152583 は論文での使用が確認できていません。

    レビューと Q&A

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