AB130062

Recombinant Human OLA1 protein (His tag N-Terminus)

Name: Recombinant Human OLA1 protein (ab130062) | Abcam
Brand: Abcam Limited
SKU: AB130062
Price: 100000 JPY
Availability: InStock

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Recombinant Human OLA1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 396 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

GTPBP9, PRO2455, PTD004, OLA1, Obg-like ATPase 1, DNA damage-regulated overexpressed in cancer 45, GTP-binding protein 9, DOC45

1 Images

SDS-PAGE - Recombinant Human OLA1 protein (His tag N-Terminus) (AB130062)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human OLA1 protein (His tag N-Terminus) (AB130062)

15% SDS-PAGE showing ab130062 (3μg).

Key facts

精製度

>95% SDS-PAGE

発現系

Escherichia coli

アプリケーション

Mass Spec, SDS-PAGE

applications

生物活性

アクセッション番号

Q9NTK5

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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製品の詳細

This product was previously labelled as GTPBP9

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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMPPKKGGDGIKPPPIIGRFGTSLKIGIVGLPNVGKSTFFNVLTNSQASAENFPFCTIDPNESRVPVPDERFDFLCQYHKPASKIPAFLNVVDIAGLVKGAHNGQGLGNAFLSHISACDGIFHLTRAFEDDDITHVEGSVDPIRDIEIIHEELQLKDEEMIGPIIDKLEKVAVRGGDKKLKPEYDIMCKVKSWVIDQKKPVRFYHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYIRKKNKWLIKIKEWVDKYDPGALVIPFSGALELKLQELSAEERQKYLEANMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFNTPQQPKKK","proteinLength":"Full Length","predictedMolecularWeight":"47.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":396,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NTK5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

OLA1 also known as Obg-like ATPase 1 is a GTPase enzyme with a molecular weight of approximately 47 kDa. It belongs to the Obg family of P-loop GTPases. You can find OLA1 primarily in the cytoplasm but it's also present in the mitochondria under certain conditions. Studies show high expression of OLA1 in a variety of tissues including the liver brain and heart indicating its widespread presence and importance in cellular processes.

Biological function summary

This protein regulates cellular processes such as protein synthesis stress response and mitochondrial function. OLA1 acts as a molecular switch influencing the dynamics of the cytoskeleton and protein synthesis machinery. It is an integral part of a multi-protein complex involved in the regulation of translation initiation factor eIF2B suggesting a role in controlling protein production during stress conditions.

Pathways

The actions of OLA1 fit into broader networks controlling cellular stress and protein homeostasis. It plays a significant role in the oxidative stress pathway and impacts the unfolded protein response. OLA1 interacts with other proteins such as HSP70 and eIF2 modulating how cells adapt to the changing environment and ensuring proper protein folding and function. This highlights its integrative role in cellular adaptation mechanisms.

OLA1 shows associations with cancer and neurodegenerative diseases. Its overexpression or mutation can contribute to tumorigenesis by affecting cell growth and apoptosis. Research also links OLA1 to Parkinson's disease where it might influence mitochondrial dysfunction interacting with proteins like Parkin and PINK1. Understanding OLA1's involvement in these disorders offers potential insights for therapeutic targets.

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製品の性状

製品の状態

Liquid

補足情報

ab130062 is purified using conventional chromatography techniques.

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一般的な情報

機能

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.

配列の類似性

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

細胞内局在性

Nucleus

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.

See full target information OLA1

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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Recombinant Human OLA1 protein (His tag N-Terminus)