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AB222981

Recombinant Human NXPH1 protein (His tag C-Terminus)

Recombinant Human NXPH1 protein (His tag C-Terminus)

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Recombinant Human NXPH1 protein (His tag C-Terminus) is a Human Full Length protein, in the 22 to 271 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

別名を表示する

NPH1, Nbla00697, NXPH1, Neurexophilin-1

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SDS-PAGE - Recombinant Human NXPH1 protein (His tag C-Terminus) (AB222981)
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Supplier Data

SDS-PAGE - Recombinant Human NXPH1 protein (His tag C-Terminus) (AB222981)

15% SDS-PAGE analysis of 3 μg ab222981.

Key facts

精製度

>90% SDS-PAGE

エンドトキシンレベル

< 1 EU/µg

発現系

Baculovirus infected insect cells

タグ

His tag C-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

P58417

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"ADPANLTNGGKSELLKSGSSKSTLKHIWTESSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSGHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"29.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":271,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"P58417","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

NXPH1 or Neurexophilin-1 is a protein involved in synaptic function. This protein weighs approximately 32 kDa and plays a role in neurotransmitter release. Researchers recognize NXPH1 by its presence in the central nervous system notably expressed in the brain. NXPH1 acts as a ligand for neurexins which are essential for synapse formation and function.
Biological function summary

Neurexophilin-1 participates in neuronal communication and acts as part of a complex with neurexins. By binding to neurexins NXPH1 influences the organization of synaptic junctions facilitating signaling between neurons. These interactions are critical for processes such as learning and memory as they support the maintenance and regulation of synaptic connections.

Pathways

NXPH1 significantly contributes to the regulation of neurotransmission and synaptic signaling. In the glutamatergic synaptic pathway NXPH1 interacts with neurexins to facilitate the release of glutamate an important neurotransmitter. Additionally it may play a role in the dopaminergic synaptic pathways by influencing dopamine receptor connectivity with proteins like neuroligins.

Neurexophilin-1 has connections to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. In these conditions alterations in NXPH1 expression or function may disrupt synaptic organization leading to impaired neuronal communication. The interaction between NXPH1 and neurexins such as NRXN1 becomes important in understanding the synaptic abnormalities observed in these disorders.
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製品の性状

製品の状態

Liquid

補足情報

Affinity purified

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一般的な情報

機能

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

配列の類似性

Belongs to the neurexophilin family.

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製品プロトコール

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ターゲットの情報

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
See full target information NXPH1
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