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Recombinant Human NFAT4/NF-ATc3 protein (ab114667)

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SDS-PAGE - Recombinant Human NFAT4/NF-ATc3 protein (ab114667)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: WB, ELISA, SDS-PAGE

    製品の詳細

    • 製品名

      Recombinant Human NFAT4/NF-ATc3 protein

    • 発現系

      Wheat germ

    • アクセッション番号

      Q12968

    • タンパク質長

      Full length protein

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVD PPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPL GGPKPFECPSIQITSISPNCHQELDAHEDDLQINDPEREFLERPSRDHLY LPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAA ARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVT DENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHS PRGSVTEDTWLNASVHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAI LPGKLELCSDDQGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFT WSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKIEVQPKTHHRAHYETE GSRGAVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAFYQVHR ITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIEL RKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELP HIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKI IREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPV LMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICS IPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGS SYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLS SIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVAD QITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPM PYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDP ASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDDQFISDLEHQPSGSA EKWPNHSVLSCPAPFWRI

      • 予測される分子量

        144 kDa

      • 領域

        1 to 1068

    特性

    Our Abpromise guarantee covers the use of ab114667 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      Western blot

      ELISA

      SDS-PAGE

    • 製品の状態

      Liquid

    • 備考

      This product was previously labelled as NFAT4.

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.3% Glutathione, 0.79% Tris HCl

    関連情報

    • 別名

      • C80703
      • cytoplasmic 3
      • D8Ertd281e
      • NF AT4
      • NF ATc3
      • NF-AT4
      • NF-ATc3
      • NFAC3_HUMAN
      • NFAT4
      • NFATc3
      • NFATx
      • Nuclear factor of activated T cells, cytoplasmic 3
      • nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
      • Nuclear factor of activated T-cells
      • T cell transcription factor NFAT4
      • T-cell transcription factor NFAT4
      see all

    • 機能

      Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.

    • 組織特異性

      Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.

    • 配列類似性

      Contains 1 RHD (Rel-like) domain.

    • ドメイン

      Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.

    • 翻訳後修飾

      Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.

    • 細胞内局在

      Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human NFAT4/NF-ATc3 protein (ab114667)
      SDS-PAGE - Recombinant Human NFAT4/NF-ATc3 protein (ab114667)
      SDS-PAGE analysis of ab114667 on a 12.5% gel stained with Coomassie Blue.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (1)

    ab114667 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab114667 は 1 報の論文で使用されています。

    • Samanta J  et al. Oleic Acid Protects from Arsenic-Induced Cardiac Hypertrophy via AMPK/FoxO/NFATc3 Pathway. Cardiovasc Toxicol 20:261-280 (2020). PubMed: 31571030

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