JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB116967

Recombinant Human NEU2 protein (GST tag N-Terminus)

Recombinant Human NEU2 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human NEU2 protein (GST tag N-Terminus) is a Human Fragment protein, in the 180 to 268 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

別名を表示する

Sialidase-2, Cytosolic sialidase, N-acetyl-alpha-neuraminidase 2, NEU2

1 Images
SDS-PAGE - Recombinant Human NEU2 protein (GST tag N-Terminus) (AB116967)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NEU2 protein (GST tag N-Terminus) (AB116967)

12.5% SDS-PAGE showing ab116967 at approximately 35.42kDa stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

ELISA, SDS-PAGE, WB

applications

生物活性

No

アクセッション番号

Q9Y3R4

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Recombinant protein.</p>" } } }
style
left-column
style
left-column

配列情報

[{"sequence":"AYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPP","proteinLength":"Fragment","predictedMolecularWeight":"35.42 kDa","actualMolecularWeight":null,"aminoAcidEnd":268,"aminoAcidStart":180,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9Y3R4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The NEU2 gene encodes for the enzyme neuraminidase 2 also known as sialidase 2. Neuraminidase 2 has a mass of approximately 42 kDa. It plays a critical role in cleaving sialic acids from glycoproteins and glycolipids. NEU2 expression is mainly found in skeletal muscle and has been noted in other tissues such as the heart and kidney. These enzyme activities are important in cell-cell communication and modulation of immune responses.
Biological function summary

Neuraminidase 2 participates in the catabolism of sialoglycoconjugates. It is not a part of a larger protein complex but acts independently to remove sialic acids which can alter the properties and functions of substrates like glycoproteins on cell surfaces. These activities impact a number of biological processes including cellular signaling pathways which can influence immune and inflammatory responses.

Pathways

Neuraminidase 2 is involved in the catabolic process of the sialyl group as part of the glycosphingolipid metabolism. It is closely linked to the lysosomal pathway impacting the degradation and recycling of biomolecules. NEU2’s enzymatic work closely relates to other neuraminidases such as NEU1 and neurominidase-3 which have overlapping functions but different tissue distributions and substrate specificities.

Deficiencies or dysfunctions in neuraminidase 2 have associations with conditions like sialidosis and galactosialidosis. These disorders arise from improper degradation of sialic acids and can impact multiple systems in the body including the central nervous system. The protein NEU1 is another neuraminidase involved in similar disorders but it primarily contributes to lysosomal storage; together they underline the importance of proper sialic acid metabolism in health.
style
left-column

製品の性状

製品の状態

Liquid

style
left-column

一般的な情報

機能

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed : 14613940, PubMed : 22228546). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed : 14613940). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (PubMed : 14613940).

配列の類似性

Belongs to the glycosyl hydrolase 33 family.

style
left-column

製品プロトコール

style
left-column

ターゲットの情報

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed : 14613940, PubMed : 22228546). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed : 14613940). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (PubMed : 14613940).
See full target information NEU2
style
left-column
style
left-column
style
right-column

組合せ製品

Proteins & Peptides

AB316501

Recombinant Human CD3 Epsilon Protein Standard (His tag)

Sandwich ELISA - Recombinant Human CD3 Epsilon Protein Standard (His tag) (AB316501)

  • 0
  • 0
Proteins & Peptides

AB290100

Recombinant Human TNF Receptor II Protein (Active)

Premium Bioactive

Biological Activity - Recombinant Human TNF Receptor II Protein (Active) (AB290100)

  • 0
  • 0
Proteins & Peptides

AB72490

Recombinant human MERTK protein

Functional Studies - Recombinant human MERTK protein (AB72490)

  • 0
  • 0
Proteins & Peptides

AB316459

Recombinant Human FGL1 Protein Standard

Sandwich ELISA - Recombinant Human FGL1 Protein Standard (AB316459)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com