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AB152670

Recombinant Human Nav1.6/SCN8A protein (GST tag N-Terminus)

Recombinant Human Nav1.6/SCN8A protein (GST tag N-Terminus)

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Recombinant Human Nav1.6/SCN8A protein (GST tag N-Terminus) is a Human Fragment protein, in the 1854 to 1951 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

別名を表示する

MED, SCN8A, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6

1 Images
SDS-PAGE - Recombinant Human Nav1.6/SCN8A protein (GST tag N-Terminus) (AB152670)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Nav1.6/SCN8A protein (GST tag N-Terminus) (AB152670)

12.5% SDS-PAGE analysis of ab152670 stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

SDS-PAGE, ELISA, WB

applications

生物活性

No

アクセッション番号

Q9UQD0

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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製品の詳細

This product was previously labelled as Nav1.6.
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配列情報

[{"sequence":"RVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVT","proteinLength":"Fragment","predictedMolecularWeight":"36.52 kDa","actualMolecularWeight":null,"aminoAcidEnd":1951,"aminoAcidStart":1854,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UQD0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Nav1.6 also known as SCN8A is a voltage-gated sodium channel with a molecular mass of approximately 260 kDa. It is well-known for its significant role in propagating action potentials in neurons. Nav1.6 is highly expressed in the central nervous system specifically in the nodes of Ranvier and axon initial segments of neurons. This channel allows the influx of sodium ions which is critical for the rapid depolarization phase of action potentials facilitating nerve signal transmission.
Biological function summary

Nav1.6 impacts neuronal excitability and firing by controlling sodium ion flow across the nerve cell membrane. It forms an integral part of the channel complex that ensures proper electrical signaling within neurons. It largely contributes to high-frequency firing and sustained repetitive firing of specific neurons which is essential for normal brain function. Alterations in Nav1.6 function can lead to abnormal electrical activity in the nervous system impacting overall neuronal communication.

Pathways

Nav1.6 participates significantly in the action potential propagation pathway. It plays a role alongside other sodium channels such as Nav1.1 and Nav1.2 to maintain the intricate balance of excitatory signals. Nav1.6 is also involved in signaling cascades that affect synaptic transmission and plasticity. In these pathways Nav1.6 interacts indirectly with various ion channels and proteins which collectively modulate neuronal excitability and plasticity important for processes like learning and memory.

Disrupted Nav1.6 function associates with epileptic encephalopathy and ataxia. Mutations in the SCN8A gene that encodes for Nav1.6 can cause abnormal channel activity leading to hyperexcitability of neurons and seizure disorders. Additionally the improper functioning of Nav1.6 links to disorders featuring motor and cognitive impairments. In these contexts Nav1.6 is commonly discussed with proteins like Nav1.2 which also contribute to pathological neuronal excitability highlighting the interconnectedness of ion channel dynamics in neurological diseases.
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient (PubMed : 24874546, PubMed : 25239001, PubMed : 25725044, PubMed : 26900580, PubMed : 29726066, PubMed : 33245860, PubMed : 36696443, PubMed : 36823201). Contributes to neuronal excitability by regulating action potential threshold and propagation (PubMed : 24874546, PubMed : 25239001, PubMed : 25725044, PubMed : 26900580, PubMed : 29726066, PubMed : 33245860, PubMed : 36696443, PubMed : 36823201).. Isoform 5. More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement.

配列の類似性

Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.

翻訳後修飾

May be ubiquitinated by NEDD4L; which would promote its endocytosis.. Phosphorylation at Ser-1497 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.

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製品プロトコール

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ターゲットの情報

Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient (PubMed : 24874546, PubMed : 25239001, PubMed : 25725044, PubMed : 26900580, PubMed : 29726066, PubMed : 33245860, PubMed : 36696443, PubMed : 36823201). Contributes to neuronal excitability by regulating action potential threshold and propagation (PubMed : 24874546, PubMed : 25239001, PubMed : 25725044, PubMed : 26900580, PubMed : 29726066, PubMed : 33245860, PubMed : 36696443, PubMed : 36823201).. Isoform 5. More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement.
See full target information SCN8A
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組合せ製品

Primary Antibodies

AB302787

Anti-Nav1.6/SCN8A antibody [EPR25137-45] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry - Anti-Nav1.6/SCN8A antibody [EPR25137-45] - BSA and Azide free (AB302787)

  • 0
  • 0
Primary Antibodies

AB53724

Anti-pan Sodium Channel antibody

Western blot - Anti-pan Sodium Channel antibody (AB53724)

  • 0
  • 0
Primary Antibodies

AB24820

Anti-Scn1a antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Scn1a antibody (AB24820)

  • 3
  • 7
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20

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