Recombinant Human MVP protein (ab153030)
Key features and details
- Expression system: Wheat germ
- Tags: GST tag N-Terminus
- Suitable for: ELISA, WB
製品の詳細
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製品名
Recombinant Human MVP protein -
発現系
Wheat germ -
タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRM VTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLY PGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGT YIPRKEVEVVEIIQATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTT VGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWL VTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKR VVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVS HQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRA VIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAKSLQPLA PRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSL SAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVN DRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIR TAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRT RDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAE KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQA LAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE AIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLG MGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR -
領域
1 to 893 -
タグ
GST tag N-Terminus
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特性
Our Abpromise guarantee covers the use of ab153030 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
ELISA
Western blot
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
関連情報
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別名
- LRP
- Lung resistance related protein
- Lung resistance-related protein
see all -
機能
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. -
組織特異性
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. -
配列類似性
Contains 9 MVP (vault) repeats. -
ドメイン
MVP 3 mediates interaction with PTEN.
MVP 4 mediates interaction with PARP4. -
翻訳後修飾
Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11. -
細胞内局在
Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment. - Information by UniProt
画像
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SDS-PAGE - Recombinant Human MVP protein (ab153030)ab153030 on a 12.5% SDS-PAGE stained with Coomassie Blue.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (1)
ab153030 は 1 報の論文で使用されています。
- Fernández R et al. Escherichia coli as a New Platform for the Fast Production of Vault-like Nanoparticles: An Optimized Protocol. Int J Mol Sci 23:N/A (2022). PubMed: 36555185
