Recombinant human MUSK protein (ab71693)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: > 85% Densitometry
- Active: Yes
- Tags: GST tag N-Terminus
- Suitable for: SDS-PAGE, Functional Studies
製品の詳細
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製品名
Recombinant human MUSK protein
MUSK タンパク質・ペプチド 製品一覧 -
生理活性
Specific activity is 6.7 nmol/min/mg.
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精製度
> 85 % Densitometry.
Affinity purified. -
発現系
Baculovirus infected Sf9 cells -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Human -
予測される分子量
63 kDa -
領域
519 to 869 -
タグ
GST tag N-Terminus -
配列の追加情報
Recombinant fragment from human MUSK, cytoplasmic domain, amino acids 519-end.
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関連製品
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Substrate reagent
特性
Our Abpromise guarantee covers the use of ab71693 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
Functional Studies
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製品の状態
Liquid -
備考
ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.0038% EGTA, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chlorideThis product is an active protein and may elicit a biological response in vivo, handle with caution.
関連情報
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別名
- CMS9
- FADS
- MDK 4
see all -
機能
Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization. -
関連疾患
Defects in MUSK is a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD) [MIM:608931]. A post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Note=MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction. -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Contains 1 FZ (frizzled) domain.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
翻訳後修飾
Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation. -
細胞内局在
Membrane. - Information by UniProt
画像
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Functional Studies - Recombinant human MUSK protein (ab71693)The specific activity of MUSK (ab71693) was determined to be 6 nmol/min/mg as per activity assay protocol
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SDS-PAGE - Recombinant human MUSK protein (ab71693)SDS PAGE analysis of ab71693 -
SDS-PAGE - Recombinant human MUSK protein (ab71693)SDS PAGE analysis of ab71693 -
Functional Studies - Recombinant human MUSK protein (ab71693) -
SDS-PAGE - Recombinant human MUSK protein (ab71693)
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab71693 は論文での使用が確認できていません。