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Recombinant Human MTPAP protein (ab162984)

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SDS-PAGE - Recombinant Human MTPAP protein (ab162984)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    製品の詳細

    • 製品名

      Recombinant Human MTPAP protein

    • 発現系

      Wheat germ

    • タンパク質長

      Full length protein

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MAVPGVGLLTRLNLCARRRTRVQRPIVRLLSCPGTVAKDLRRDEQPSGSV ETGFEDKIPKRRFSEMQNERREQAQRTVLIHCPEKISENKFLKYLSQFGP INNHFFYESFGLYAVVEFCQKESIGSLQNGTHTPSTAMETAIPFRSRFFN LKLKNQTSERSRVRSSNQLPRSNKQLFELLCYAESIDDQLNTLLKEFQLT EENTKLRYLTCSLIEDMAAAHFPDCIVRPFGSSVNTFGKLGCDLDMFLDL DETRNLSAHKISGNFLMEFQVKNVPSERIATQKILSVLGECLDHFGPGCV GVQKILNARCPLVRFSHQASGFQCDLTTNNRIALTSSELLYIYGALDSRV RALVFSVRCWARAHSLTSSIPGAWITNFSLTMMVIFFLQRRSPPILPTLD SLKTLADAEDKCVIEGNNRTFVRDLSRIKPSQNTETLELLLKEFFEYFGN FAFDKNSINIRQGREQNKPDSSPLYIQNPFETSLNISKNVSQSQLQKFVD LARESAWILQQEDTDRPSISSNRPWGLVSLLLPSAPNRKSFTKKKNNKFA IETVKNLLESLKGNRTENFTKTSGKRTISTQT

      • 領域

        1 to 582

      • タグ

        GST tag N-Terminus

    特性

    Our Abpromise guarantee covers the use of ab162984 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      ELISA

      Western blot

    • 製品の状態

      Liquid

    • 備考

      This product was previously labelled as Poly(A) RNA polymerase.

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    関連情報

    • 別名

      • 0610027A18Rik
      • AW551379
      • EC 2.7.7.19
      • FLJ10486
      • mitochondrial
      • Mitochondrial poly(A) polymerase
      • mtPAP
      • PAP
      • PAP-associated domain-containing protein 1
      • PAPD1
      • PAPD1_HUMAN
      • Poly(A) RNA polymerase
      • Poly(A) RNA polymerase, mitochondrial
      • Poly(A) RNA polymerase, mitochondrial precursor
      • Polynucleotide adenylyltransferase
      • RP11-305E6.3
      • Terminal uridylyltransferase 1
      • TUTase 1
      see all

    • 機能

      Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.

    • 組織特異性

      Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle.

    • 関連疾患

      Defects in MTPAP are the cause of spastic ataxia autosomal recessive type 4 (SPAX4) [MIM:613672]. A slowly progressive neurodegenerative disease characterized by cerebellar ataxia, spastic paraparesis, dysarthria, and optic atrophy. Note=Affected individuals exhibit a drastic decrease in poly(A) tail length of representative mitochondrial mRNA transcripts, including COX1 and RNA14 (PubMed:20970105).

    • 配列類似性

      Belongs to the DNA polymerase type-B-like family.
      Contains 1 PAP-associated domain.

    • 細胞内局在

      Cytoplasm. Mitochondrion.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human MTPAP protein (ab162984)
      SDS-PAGE - Recombinant Human MTPAP protein (ab162984)
      ab162984 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab162984 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab162984 は論文での使用が確認できていません。

    レビューと Q&A

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