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AB153171

Recombinant Human MRPL3 protein (GST tag N-Terminus)

Recombinant Human MRPL3 protein (GST tag N-Terminus)

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Recombinant Human MRPL3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 348 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

MRL3, RPML3, MRPL3, Large ribosomal subunit protein uL3m, L3mt, MRP-L3

1 Images
SDS-PAGE - Recombinant Human MRPL3 protein (GST tag N-Terminus) (AB153171)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MRPL3 protein (GST tag N-Terminus) (AB153171)

ab153171 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

ELISA, WB

applications

生物活性

No

アクセッション番号

P09001

アニマルフリー

No

キャリアフリー

No

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

配列情報

[{"linker":null,"sequence":"MPGWRLLTQVGAQVLGRLGDGLGAALGPGNRTHIWLFVRGLHGKSGTWWDEHLSEENVPFIKQLVSDEDKAQLASKLCPLKDEPWPIHPWEPGSFRVGLIALKLGMMPLWTKDGQKHVVTLLQVQDCHVLKYTSKENCNGKMATLSVGGKTVSRFRKATSILEFYRELGLPPKQTVKIFNITDNAAIKPGTPLYAAHFRPGQYVDVTAKTIGKGFQGVMKRWGFKGQPATHGQTKTHRRPGAVATGDIGRVWPGTKMPGKMGNIYRTEYGLKVWRINTKHNIIYVNGSVPGHKNCLVKVKDSKLPAYKDLGKNLPFPTYFPDGDEEELPEDLYDENVCQPGAPSITFA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":348,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P09001","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Proprietary technique
出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MRPL3 also known as Mitochondrial Ribosomal Protein L3 functions mechanically as a component of the mitochondrial ribosome specifically the large 39S subunit. This protein plays a role in mitochondrial protein synthesis. MRPL3 has a molecular mass of approximately 35 kDa. It is expressed in the mitochondria across various tissues having a pivotal involvement in the synthesis of proteins essential for mitochondrial energy generation.
Biological function summary

MRPL3 is important for the production of mitochondrial proteins by facilitating the translation of mitochondrial mRNA molecules. It forms part of the mitochondrial ribosome complex which is distinct from cytoplasmic ribosomes due to its protein-rich composition and specific ribosomal RNA components. This unique ribosome composition allows MRPL3 to contribute to mitochondrial-specific translational mechanisms that support cellular respiration and energy production.

Pathways

MRPL3 is notably involved in mitochondrial translation and oxidative phosphorylation pathways. In the context of oxidative phosphorylation MRPL3 works alongside other mitochondrial ribosomal proteins like MRPS23 to ensure the proper translation of essential components of the electron transport chain. This pathway is important for ATP production which cells use as an energy source. Efficient functioning of these pathways relies on proteins produced through the process that involves MRPL3.

MRPL3 is associated with mitochondrial diseases and certain forms of cancer due to its role in energy metabolism and protein synthesis. Mutations or dysregulation in MRPL3 may lead to mitochondrial dysfunction resulting in conditions such as mitochondrial cardiomyopathy. In some cancers MRPL3 expression levels can alter linked with changes in cellular energy demands and protein synthesis. The protein MRPL44 has shown to interact with MRPL3 suggesting a contribution to the pathology when mitochondrial protein synthesis is impaired.

一般的な情報

配列の類似性

Belongs to the universal ribosomal protein uL3 family.

細胞内局在性

Mitochondrion

製品プロトコール

ターゲットの情報

See full target information MRPL3

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