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AB255808

Recombinant Human/Mouse/Rat Inhibin beta A protein (Active)

Recombinant Human/Mouse/Rat Inhibin beta A protein (Active)

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Recombinant Human/Mouse/Rat Inhibin beta A protein (Active) is a Human Full Length protein, in the 311 to 426 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

別名を表示する

Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA

2 Images
Functional Studies - Recombinant Human/Mouse/Rat Inhibin beta A protein (Active) (AB255808)
  • FuncS

Supplier Data

Functional Studies - Recombinant Human/Mouse/Rat Inhibin beta A protein (Active) (AB255808)

Functional activity of ab255808.

SDS-PAGE - Recombinant Human/Mouse/Rat Inhibin beta A protein (Active) (AB255808)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human/Mouse/Rat Inhibin beta A protein (Active) (AB255808)

SDS-PAGE analysis of ab255808 (1μg) under reducing (+) and non-reducing (-) conditions.

Key facts

精製度

>95% SDS-PAGE

エンドトキシンレベル

< 1 EU/µg

発現系

Escherichia coli

タグ

Tag free

アプリケーション

FuncS, SDS-PAGE

applications

生物活性

Yes

生物学的活性

Cytotoxicity of MPC-11 cells: ≤10 ng/mL; ≥ 1.0 x 105 units/mg

アクセッション番号

P08476

アニマルフリー

Yes

キャリアフリー

No

種

Human

再構成

Reconstitute at 0.1 mg/mL in water

バッファー組成

Constituents: 0.1% Trifluoroacetic acid

storage-buffer

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組合せ製品

Proteins & Peptides

AB285462

Recombinant human FGF2 protein (Active)

Bioactive

Functional Studies - Recombinant human FGF2 protein (Active) (AB285462)

  • 0
  • 0
Multiplex Kits

AB193657

Human Cytokine Antibody Array - Membrane (174 Targets)

Multiplex Protein Detection - Human Cytokine Antibody Array - Membrane (174 Targets) (AB193657)

  • 0
  • 0
Primary Antibodies

AB97705

Anti-Inhibin beta A antibody

Immunocytochemistry/ Immunofluorescence - Anti-Inhibin beta A antibody (AB97705)

  • 0
  • 0
Proteins & Peptides

AB238298

Recombinant human BMP4 protein (Active)

Bioactive

Functional Studies - Recombinant human BMP4 protein (Active) (AB238298)

  • 5
  • 2
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"MGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS","proteinLength":"Full Length","predictedMolecularWeight":"13.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":426,"aminoAcidStart":311,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P08476","tags":[]}]
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出荷温度及び保存条件

製品の状態
Lyophilized
出荷温度
Ambient - Can Ship with Ice
短期保存温度
-80°C
長期保存温度
-80°C
保管に関する情報
Avoid freeze / thaw cycle
True
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Inhibin beta A also known as activin beta A chain and inhibin A is a protein with a significant role in the regulation of diverse physiological processes. This protein has a molecular mass of approximately 45 kDa and originates primarily from gonadal tissues but also from the placenta pituitary gland and other tissues. Inhibin beta A consists of several subunits that can dimerize to form both activins and inhibins depending on the pairing with other subunits like the alpha chain.
Biological function summary

Activin beta A chain plays an important role in the modulation of follicle-stimulating hormone (FSH) regulation cellular growth and differentiation. It often functions as part of a complex with activin and inhibin proteins influencing reproductive hormone levels and participating in tissue repair and inflammation processes. Inhibin beta A forms activin A when paired with another inhibin beta A subunit or inhibin A when paired with an inhibin alpha subunit therefore contributing to the modulation of FSH-releasing protein activity.

Pathways

Activin and inhibin proteins participate in the regulation of the TGF-beta signaling pathway which is essential for reproductive and developmental processes. In this context inhibin beta A interacts functionally with proteins such as follistatin and FSH-releasing protein which modulate pathways that influence follicle maturation and hormone secretion. The protein's role in these pathways highlights its importance in orchestrating hormonal responses and facilitating proper cellular communication within the endocrine system.

Inhibin beta A becomes relevant in the context of reproductive health and oncology. Changes in its expression can associate with disorders like polycystic ovary syndrome (PCOS) and certain cancers particularly ovarian cancer where it may alter hormonal regulation and tumor progression. Related proteins such as inhibin B and follistatin also play roles in these conditions further complicating the pathways and the potential development of therapeutic interventions that target inhibin beta A and its network of interactions.
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一般的な情報

機能

Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.. Activin A is a homodimer of INHBA that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis (PubMed : 3194407, PubMed : 16440334). Signals through type I (such as ACVR1B or ACVR1C) and type II receptors (such as ACVR2A, ACVR2B or BMPR2) which, upon ligand binding, phosphorylate SMAD2 and SMAD3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and modulate gene expression (PubMed : 10652306, PubMed : 24018044). Can also activate alternative non-canonical intracellular signaling pathways including the p38 MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNKs) to modulate cell migration and differentiation (PubMed : 16440334). Alternatively, promotes osteoblastic differentiation via ACVRL1-SMAD1/5/9 pathway (PubMed : 34948289). In addition, can engage the type I receptor ACVR1 to form an ACVR1-activin A-type II receptor non-signaling complex (NSC) that renders receptors unavailable for engagement with BMPs, hence resulting in an apparent inhibition of ACVR1-mediated BMP signaling (PubMed : 26333933).. Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor.

配列の類似性

Belongs to the TGF-beta family.

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製品プロトコール

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ターゲットの情報

Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.. Activin A is a homodimer of INHBA that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis (PubMed : 3194407, PubMed : 16440334). Signals through type I (such as ACVR1B or ACVR1C) and type II receptors (such as ACVR2A, ACVR2B or BMPR2) which, upon ligand binding, phosphorylate SMAD2 and SMAD3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and modulate gene expression (PubMed : 10652306, PubMed : 24018044). Can also activate alternative non-canonical intracellular signaling pathways including the p38 MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNKs) to modulate cell migration and differentiation (PubMed : 16440334). Alternatively, promotes osteoblastic differentiation via ACVRL1-SMAD1/5/9 pathway (PubMed : 34948289). In addition, can engage the type I receptor ACVR1 to form an ACVR1-activin A-type II receptor non-signaling complex (NSC) that renders receptors unavailable for engagement with BMPs, hence resulting in an apparent inhibition of ACVR1-mediated BMP signaling (PubMed : 26333933).. Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor.
See full target information Inhibin beta A chain
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