Recombinant Human Motilin protein

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Motilin is a peptide hormone weighing approximately 22 kDa mainly produced and secreted by the M cells in the small intestine. Some researchers refer to it as 'the housekeeper of the gut' due to its role in intestinal motility. It is also present in lower amounts in the hypothalamus. This target acts mechanically by binding motilin receptors which are widespread in the gastrointestinal tract and facilitate the initiation of migrating motor complexes (MMCs) that facilitate smooth muscle contractions.

Biological function summary

Motilin controls certain gastrointestinal processes during fasting states. It plays an important role in regulating the MMCs which are important for clearing non-digestible substances from the stomach and small intestine. Despite not being part of a larger complex motilin's effects on gastric and intestinal motility are essential for maintaining gastrointestinal health. The signal from motilin influences smooth muscle contractions and enzyme secretions which are critical for digestive processes.

Pathways

Motilin is an integral part of the motility regulation pathway in the gastrointestinal system. In this pathway it interacts with several key proteins including the motilin receptor which triggers the cascading events leading to muscle contractions. It is also indirectly associated with the ghrelin pathway as ghrelin can augment the effects of motilin although they act through separate receptors.

Disruptions involving motilin often link to gastrointestinal conditions. For instance abnormal motilin levels or receptor activity associate with gastroparesis a condition where delayed gastric emptying causes digestive disruption. Likewise some cases of irritable bowel syndrome (IBS) involve altered motilin signaling. These conditions also exhibit interactions with other proteins like ghrelin and its receptor as these proteins collectively mediate gastrointestinal motility and hunger signals.