AB158890

Recombinant Human MGST2 protein (GST tag N-Terminus)

Name: Recombinant Human MGST2 protein (ab158890) | Abcam
Brand: Abcam Limited
SKU: AB158890
Price: 118000 JPY
Availability: InStock

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Recombinant Human MGST2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 147 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

GST2, MGST2, Microsomal glutathione S-transferase 2, Microsomal GST-2, Glutathione peroxidase MGST2, Leukotriene C4 synthase MGST2, Microsomal glutathione S-transferase II, Microsomal GST-II

1 Images

SDS-PAGE - Recombinant Human MGST2 protein (GST tag N-Terminus) (AB158890)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MGST2 protein (GST tag N-Terminus) (AB158890)

ab158890 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

アプリケーション

ELISA, WB

applications

生物活性

アクセッション番号

Q99735

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKKLRRQF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":147,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q99735","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Dry Ice

短期保存温度

-80°C

長期保存温度

-80°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Microsomal glutathione S-transferase 2 (MGST2) is an important enzyme involved in detoxification processes within the body. MGST2 is alternatively known as GST2 or FXC1. The protein has a molecular mass of approximately 13 kDa and is expressed in various tissues including the liver lungs and kidneys where it plays a significant role in defending cells against oxidative stress. It functions by catalyzing the conjugation of glutathione to toxic substances facilitating their removal from the body.

Biological function summary

MGST2 impacts cellular defense by aiding in the detoxification of harmful compounds. It operates as part of a larger complex often associating with other glutathione transferases. By facilitating the breakdown of reactive oxygen species and electrophiles MGST2 helps in protecting cells from damage. This protection is especially important in metabolically active tissues where reactive by-products are more frequent.

Pathways

MGST2 is a component of the glutathione metabolism pathway where it collaborates closely with related proteins such as GSTM1 and GSTT1. It also plays a role in the arachidonic acid metabolism pathway. MGST2 interacts with enzymes important for the synthesis of leukotrienes which are signaling molecules involved in the inflammatory response. These pathways highlight MGST2's role in maintaining cellular homeostasis and responding to stress.

MGST2 has been linked to certain conditions due to its role in detoxification and inflammation. Impaired function of this enzyme can be connected to liver disease where inefficient clearance of toxins can exacerbate hepatic damage. MGST2 has also been implicated in inflammatory diseases like asthma where its interaction with leukotriene-related proteins influences inflammatory pathways. Understanding MGST2's role in these diseases may offer insights into new therapeutic targets.

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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Catalyzes several different glutathione-dependent reactions (PubMed : 23409838, PubMed : 26066610, PubMed : 26656251, PubMed : 8703034, PubMed : 9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed : 23409838, PubMed : 9278457). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed : 23409838, PubMed : 8703034). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed : 23409838, PubMed : 26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed : 26656251).

配列の類似性

Belongs to the MAPEG family.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information MGST2

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Abcam product promise

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Recombinant Human MGST2 protein (GST tag N-Terminus)