AB158883

Recombinant Human MFI2/MTf protein

Name: Recombinant Human MFI2/MTf protein (ab158883) | Abcam
Brand: Abcam Limited
SKU: AB158883
Price: 118000 JPY
Availability: InStock

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Recombinant Human MFI2/MTf protein is a Human Full Length protein, in the 21 to 302 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

CD228, MAP97, MFI2, MELTF, Melanotransferrin, Melanoma-associated antigen p97

1 Images

SDS-PAGE - Recombinant Human MFI2/MTf protein (AB158883)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MFI2/MTf protein (AB158883)

ab158883 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

アプリケーション

ELISA, WB

applications

生物活性

アクセッション番号

P08582

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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製品の詳細

This product was previously labelled as MFI2.

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配列情報

[{"sequence":"MEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDHFGGSCVPGAGETSYSESLCRLCRGDSPGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDESPSRRQTWTRSEEEEGECPAHEEARRTMRSSAGQAWKWAPVHRPQDESDKGEFGKRAKSRDMLG","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":302,"aminoAcidStart":21,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P08582","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Dry Ice

短期保存温度

-80°C

長期保存温度

-80°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MFI2/MTf also known as melanotransferrin or p97 is a membrane-associated glycoprotein with a mass of approximately 70 kDa. This target is expressed in various tissues including marmoset breast tissue and is notably abundant in the brain and skin. MFI2/MTf exhibits a pivotal role at the cell surface where it interacts with transferrin receptors and heparan sulfate proteoglycans. Although associated with iron metabolism it does not bind iron directly but plays a part in the cellular uptake of iron.

Biological function summary

MFI2/MTf participates in cellular processes related to growth and development. It is involved in promoting cell proliferation and migration and its expression is upregulated in several cancers indicating a possible role in tumor growth. MFI2/MTf does not form a part of a larger known complex but interacts with other molecules at the cell surface that influence its activity. Researchers consider it an important marker for both physiological growth and pathological conditions like malignancies.

Pathways

MFI2/MTf functions as an important player in the iron homeostasis and MAPK signaling pathways. It interacts with proteins such as the transferrin receptor and various growth factor receptors. These interactions contribute to pathways governing cellular proliferation and survival. Its engagement in these pathways suggests that MFI2/MTf is important for maintaining cellular functions that rely on iron metabolism and signal transduction which are critical in both normal and disease states.

MFI2/MTf has associations with melanoma and neurodegenerative conditions such as Alzheimer's disease. In melanoma it integrates into mechanisms involving other proteins like metalloproteinases enhancing invasive capabilities. In neurodegenerative contexts an aberrant expression or altered function of MFI2/MTf might contribute to pathological processes potentially involving interactions with amyloid precursor proteins. These connections highlight the significance of MFI2/MTf in understanding and possibly targeting these disorders.

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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

配列の類似性

Belongs to the transferrin family.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

See full target information MELTF

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Abcam product promise

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Recombinant Human MFI2/MTf protein