AB219453

Recombinant Human MFAP4 protein (His tag C-Terminus)

Name: Recombinant Human MFAP4 protein (His tag) (ab219453) | Abcam
Brand: Abcam Limited
SKU: AB219453
Price: 109000 JPY
Availability: InStock

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Recombinant Human MFAP4 protein (His tag C-Terminus) is a Human Full Length protein, in the 22 to 255 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

別名を表示する

Microfibril-associated glycoprotein 4, MFAP4

1 Images

SDS-PAGE - Recombinant Human MFAP4 protein (His tag) (AB219453)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MFAP4 protein (His tag) (AB219453)

15% SDS-PAGE using 3ug of ab219453. Molecular Weight : 27.5kDa; 28-40KDa (SDS-PAGE under reducing conditions.)

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Key facts

精製度

>90% SDS-PAGE

エンドトキシンレベル

< 1 EU/µg

発現系

Baculovirus infected insect cells

アプリケーション

SDS-PAGE

applications

生物活性

アクセッション番号

P55083

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"ADLVSGIRGDALERFCLQQPLDCDDIYAQGYQSDGVYLIYPSGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWNDYKLGFGRADGEYWLGLQNMHLLTLKQKYELRVDLEDFENNTAYAKYADFSISPNAVSAEEDGYTLFVAGFEDGGAGDSLSYHSGQKFSTFDRDQDLFVQNCAALSSGAFWFRSCHFANLNGFYLGGSHLSYANGINWAQWKGFYYSLKRTEMKIRRAHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"27.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":255,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"P55083","tags":[{"tag":"His","terminus":"C-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MFAP4 also known as Microfibril-Associated Glycoprotein 4 is a protein that plays a significant role in the extracellular matrix architecture. The molecular mass of MFAP4 is about 29 kDa. This protein is expressed in various tissues including the lung liver heart and blood vessels. As a part of the extracellular matrix MFAP4 contributes to the structural integrity and elasticity of connective tissues.

Biological function summary

MFAP4 interacts with components of the microfibrillar network. It is not a standalone entity but functions as part of a larger complex that includes elastin and microfibrillin-1. This association enhances the mechanical properties of tissues maintaining them against pressure and stretch forces. MFAP4 also participates in cellular responses such as cell adhesion and migration which are critical for tissue remodeling and repair processes.

Pathways

MFAP4 engages in multiple biological pathways related to the extracellular matrix and tissue homeostasis. The TGF-beta signaling pathway is notable as MFAP4 interacts with multiple proteins within this pathway such as fibrillin-1. Through these interactions MFAP4 influences the regulation of cell growth and differentiation. Another pathway is the integrin signaling pathway where its association with integrins supports cell adhesion and communication within the extracellular matrix.

MFAP4 shows associations with fibrosis and chronic obstructive pulmonary disease (COPD). Both conditions involve alterations in the extracellular matrix composition and function. In fibrosis the dysregulated expression of MFAP4 can affect connective tissue remodeling. Altered MFAP4 levels have also been observed in COPD where it may impact lung tissue elasticity. The protein connects with TGF-beta in the context of these diseases influencing abnormal tissue remodeling and inflammation processes.

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製品の性状

製品の状態

Liquid

補足情報

Affinity purified

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一般的な情報

機能

Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed : 26601954).

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製品プロトコール

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ターゲットの情報

Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed : 26601954).

See full target information MFAP4

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Abcam product promise

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Recombinant Human MFAP4 protein (His tag C-Terminus)