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Recombinant Human METTL3 protein (ab163377)

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SDS-PAGE - Recombinant Human METTL3 protein (ab163377)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: WB, ELISA

    製品の詳細

    • 製品名

      Recombinant Human METTL3 protein
      METTL3 タンパク質・ペプチド 製品一覧

    • 発現系

      Wheat germ

    • タンパク質長

      Full length protein

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDS PVPTAPTSGGPKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSI CLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADH SKLSAMMGAVAEKKGPGEVAGTVTGQKRRAEQDSTTVAAFASSLVSGLNS SASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELL NTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFR RIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPS QELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDI HMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYE RVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDC DVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQ LDGIHLLDPDVVARFKQRYPDGIISKPKNL

      • 領域

        1 to 580

      • タグ

        GST tag N-Terminus

    関連製品

    特性

    Our Abpromise guarantee covers the use of ab163377 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      Western blot

      ELISA

    • 製品の状態

      Liquid

    • 備考

       

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    関連情報

    • 別名

      • adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
      • IME4
      • M6A
      • Methyltransferase like protein 3
      • Methyltransferase-like protein 3
      • METTL3
      • mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
      • mRNA m(6)A methyltransferase
      • MT-A70
      • MTA70
      • MTA70_HUMAN
      • N6 adenosine methyltransferase 70 kDa subunit
      • N6-adenosine-methyltransferase 70 kDa subunit
      see all

    • 機能

      N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation.

    • 組織特異性

      Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

    • 配列類似性

      Belongs to the MT-A70-like family.

    • 翻訳後修飾

      Phosphorylated upon DNA damage, probably by ATM or ATR.

    • 細胞内局在

      Nucleus speckle. Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human METTL3 protein (ab163377)
      SDS-PAGE - Recombinant Human METTL3 protein (ab163377)
      ab163377 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab163377 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab163377 は論文での使用が確認できていません。

    レビューと Q&A

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