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Recombinant Human Methionine Aminopeptidase 2/p67 protein (ab168057)

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Key features and details

  • Expression system: Insect cells
  • Purity: > 95% SDS-PAGE
  • Suitable for: SDS-PAGE

製品の詳細

  • 製品名

    Recombinant Human Methionine Aminopeptidase 2/p67 protein
    Methionine Aminopeptidase 2/p67 タンパク質・ペプチド 製品一覧

  • 精製度

    > 95 % SDS-PAGE.
    ab168057 was purified by chromatography.

  • 発現系

    Insect cells

  • アクセッション番号

    P50579

  • タンパク質長

    Full length protein

  • Animal free

    No

  • 由来

    Recombinant

    • 生物種

      Human

    • 配列

      MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSA AGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKK KKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRT TSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKL EDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKI DFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGG EATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTK HLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDI KGSYTAQFEHTILLRPTCKEVVSRGDDY

    • 予測される分子量

      70 kDa including tags

    • 領域

      1 to 478

特性

Our Abpromise guarantee covers the use of ab168057 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態

    Liquid

  • 備考

     This product was previously labelled as Methionine Aminopeptidase 2

     

    Abcam has not and does not intend to apply for the REACH Authorisation of customers’ uses of products that contain European Authorisation list (Annex XIV) substances.
    It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium azide
    Constituents: 0.48% HEPES, 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.001% Cobalt chloride

関連情報

  • 別名

    • A930035J23Rik
    • AI047573
    • AL024412
    • Amp2
    • AU014659,
    • EIF 2 associated p67 homolog
    • EIF-2-associated p67
    • Initiation factor 2 associated 67 kDa glycoprotein
    • Initiation factor 2-associated 67 kDa glycoprotein
    • MAP 2
    • MAP2
    • MAP2_HUMAN
    • MetAP 2
    • Metap2
    • Methionine aminopeptidase 2
    • Methionyl aminopeptidase 2
    • MGC102452
    • MGC127390
    • MGC53792
    • MNPEP
    • p67
    • p67eIF2
    • Peptidase M
    • Peptidase M2
    see all

  • 機能

    Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
    Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

  • 配列類似性

    Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.

  • 翻訳後修飾

    Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.

  • 細胞内局在

    Cytoplasm. About 30% of expressed METAP2 associates with polysomes.
  • Information by UniProt

プロトコール

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

参考文献 (0)

ab168057 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab168057 は論文での使用が確認できていません。

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