Recombinant Human Mesothelin protein (Fc Chimera) (ab185268)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 1.000 Eu/µg
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Recombinant Human Mesothelin protein (Fc Chimera)
Mesothelin タンパク質・ペプチド 製品一覧 -
精製度
> 95 % SDS-PAGE. -
エンドトキシン・レベル
< 1.000 Eu/µg -
発現系
HEK 293 cells -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
EVEKTACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ VATLIDRFVK DWILRQRQDD LDTLGLGLQG -
予測される分子量
60 kDa including tags -
領域
296 to 580 -
配列の追加情報
Fused with Fc fragment of human IgG1 at the N-terminus. AAH09272.
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特性
Our Abpromise guarantee covers the use of ab185268 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Lyophilized -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at 4°C prior to reconstitution. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
pH: 7.4
Constituents: 0.61% Tris, 0.75% Glycine, 5% Trehalose -
再構成Reconstitute with sterile deionized water to a concentration of 1 mg/ml.
関連情報
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別名
- CAK 1
- CAK1
- CAK1 antigen
see all -
機能
Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. -
組織特異性
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). -
関連疾患
Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. -
配列類似性
Belongs to the mesothelin family. -
翻訳後修飾
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. -
細胞内局在
Secreted and Cell membrane. Golgi apparatus. - Information by UniProt
画像
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SDS-PAGE - Recombinant Human Mesothelin protein (Fc Chimera) (ab185268)
SDS-PAGE analysis of DTT-reduced (lane 1) and non-reduced (lane 2) staining overnight with Coomassie Blue. DTT-reduced Protein migrates as 60-68 kDa and non-reduced protein migrates as 120-130 kDa.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab185268 は論文での使用が確認できていません。
