Recombinant Human Mesothelin protein (ab245958)
Key features and details
- Expression system: CHO cells
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 1.000 Eu/µg
- Suitable for: SDS-PAGE, Functional Studies, HPLC
製品の詳細
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製品名
Recombinant Human Mesothelin protein
Mesothelin タンパク質・ペプチド 製品一覧 -
精製度
> 95 % SDS-PAGE.
Greater than 95% by HPLC analyses. -
エンドトキシン・レベル
< 1.000 Eu/µg -
発現系
CHO cells -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
LAGETGQEAAPLDGVLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELA VALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQA CTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALG GLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGP PSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPER -
予測される分子量
27 kDa -
領域
37 to 286 -
配列の追加情報
Corresponding to aa 37-286 Megakaryocyte-potentiating factor chain.
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特性
Our Abpromise guarantee covers the use of ab245958 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
Functional Studies
HPLC
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製品の状態
Lyophilized -
備考
As a result of glycosylation, ab245958 migrates with an apparent molecular mass of approximately 32-33 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituent: 0.16% Sodium phosphate
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再構成Reconstitute in water to 0.1 - 1.0 mg/ml.
関連情報
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別名
- CAK 1
- CAK1
- CAK1 antigen
see all -
機能
Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. -
組織特異性
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). -
関連疾患
Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. -
配列類似性
Belongs to the mesothelin family. -
翻訳後修飾
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. -
細胞内局在
Secreted and Cell membrane. Golgi apparatus. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab245958 は論文での使用が確認できていません。
