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AB167832

Recombinant Human KLF3 protein (denatured)

Recombinant Human KLF3 protein (denatured)

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Recombinant Human KLF3 protein (denatured) is a Human protein, in the 1 to 345 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

別名を表示する

BKLF, KLF3, Krueppel-like factor 3, Basic krueppel-like factor, CACCC-box-binding protein BKLF, TEF-2

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SDS-PAGE - Recombinant Human KLF3 protein (denatured) (AB167832)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human KLF3 protein (denatured) (AB167832)

15% SDS-PAGE analysis of ab167832 (3µg).

Key facts

精製度

>90% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

P57682

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLMFDPVPVKQEAMDPVSVSYPSNYMESMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSSHRRASPGLSMPSSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV","proteinLength":null,"predictedMolecularWeight":"41.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":345,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P57682","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

KLF3 also known as BKLF (Basic Krüppel-like Factor) is a transcription factor weighing approximately 40 kDa. It regulates gene expression by binding to specific DNA sequences generally influencing various cellular processes. KLF3 is expressed in diverse tissues such as hematopoietic cells and adipose tissues among others. Its presence is observed in both normal physiological conditions and under certain stresses indicating a broader regulatory role.
Biological function summary

KLF3 acts as a major regulator of cell differentiation and proliferation. It functions as part of a transcriptional complex interacting with co-factors to modulate gene networks. Through its zinc finger domains KLF3 binds to DNA and influences the transcription of genes involved in erythropoiesis the process that produces red blood cells and adipogenesis the formation of fat cells. These biological roles suggest that KLF3 maintains homeostasis in tissue development and maturation.

Pathways

Multiple cellular events involve KLF3. It significantly contributes to the TGF-beta signaling pathway and the erythropoiesis pathway. Within these pathways KLF3 interacts with other proteins like TGF-beta receptors and other transcription factors like GATA1. This interaction helps drive transcriptional changes necessary for these pathways' completion indicating KLF3's integral role.

KLF3 plays a part in several conditions including obesity and anemia. In obesity alteration in KLF3 expression affects adipogenesis impacting fat cell formation and accumulation. In anemia KLF3 dysregulation leads to improper erythropoiesis due to its interaction with proteins like GATA1 and EPOR (erythropoietin receptor). These associations underline KLF3's potential implications in managing metabolic and blood disorders.
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).

配列の類似性

Belongs to the krueppel C2H2-type zinc-finger protein family.

翻訳後修飾

Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-198 is the major site (By similarity).

細胞内局在性

Nucleus

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製品プロトコール

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ターゲットの情報

Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).
See full target information KLF3
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組合せ製品

Primary Antibodies

AB154531

Anti-KLF3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF3 antibody (AB154531)

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