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AB160141

Recombinant Human Keratin 36 protein (GST tag N-Terminus)

Recombinant Human Keratin 36 protein (GST tag N-Terminus)

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Recombinant Human Keratin 36 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 417 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

HHA6, HKA6, KRTHA6, KRT36, Keratin-36, K36

1 Images
SDS-PAGE - Recombinant Human Keratin 36 protein (GST tag N-Terminus) (AB160141)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Keratin 36 protein (GST tag N-Terminus) (AB160141)

ab160141 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

WB, ELISA

applications

生物活性

No

アクセッション番号

O76013

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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組合せ製品

Reagents, Controls & Accessories

AB234617

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB234617)

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Primary Antibodies

AB111599

Anti-Keratin 36 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Keratin 36 antibody (AB111599)

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Proteins & Peptides

AB119460

Recombinant Human p18 INK4c/CDKN2C protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human p18 INK4c/CDKN2C protein (His tag N-Terminus) (AB119460)

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Proteins & Peptides

AB113589

Recombinant Human MAFG protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human MAFG protein (His tag N-Terminus) (AB113589)

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Proteins & Peptides

AB103303

Recombinant E. coli Ecotin protein (His tag N-Terminus)

SDS-PAGE - Recombinant E. coli Ecotin protein (His tag N-Terminus) (AB103303)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"MLRSGLSGLGSCLPGSYLSSECHTSGFVGSGGWFCEGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLERQNQEYQVLLDVKARLEGEIATYRHLLEGEDCKLPPQPCATACKPVIRVPSVPPVPCVPSVPCTPAPQVGTQIRTITEEIRDGKVISSREHVQSRPL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":417,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O76013","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Proprietary technique
出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Keratin 36 also known as KRT36 or K6HF is a type I keratin protein within the keratin family. The protein has a mass of approximately 50 kDa. This protein primarily expresses in hair follicles particularly in the inner root sheath and the hair shaft cortex. Keratin 36 contributes to the mechanical stability and integrity of hair fibers assisting in forming and maintaining the strength and resilience of the hair structure.
Biological function summary

Keratin 36 serves an important role in the structural framework of epithelial cells specifically those contributing to keratinocyte function and hair formation. It forms intermediate filaments as part of a larger keratin complex interacting with other keratins such as type II hard keratins in hair and nails. These interactions help establish the strong and insoluble nature of the protective barriers where keratin is present.

Pathways

Keratin 36 participates in intricate signaling related to hair follicle morphogenesis and differentiation. It is involved in the epithelial structural complex working alongside pathways such as the Wnt signaling pathway and the epidermal growth factor (EGF) signaling pathway. Related proteins like Keratin 35 and Keratin 85 also play essential roles in these pathways further integrating with the processes governing hair and skin tissue formation.

Keratin 36 mutations or dysregulation link to conditions like hair disorders and keratoderma. Specifically hereditary conditions such as monilethrix characterized by brittle beaded hair show associations with alterations in keratin expression patterns. Keratin 36 interacts with proteins like Filaggrin and Loricrin in these contexts which are also involved in related structural disorders of the skin.
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一般的な情報

配列の類似性

Belongs to the intermediate filament family.

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製品プロトコール

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ターゲットの情報

See full target information KRT36
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