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Recombinant Human KDM2A protein (ab151923)

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SDS-PAGE - Recombinant Human KDM2A protein (ab151923)

    Key features and details

    • Expression system: Baculovirus infected Sf9 cells
    • Purity: > 90% Densitometry
    • Suitable for: WB, SDS-PAGE

    製品の詳細

    • 製品名

      Recombinant Human KDM2A protein
      KDM2A タンパク質・ペプチド 製品一覧

    • 精製度

      > 90 % Densitometry.
      Affinity purified.

    • 発現系

      Baculovirus infected Sf9 cells

    • アクセッション番号

      Q9Y2K7

    • タンパク質長

      Protein fragment

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MEPEEERIRY SQRLRGTMRR RYEDDGISDD EIEGKRTFDL EEKLHTNKYN ANFVTFMEGK DFNVEYIQRG GLRDPLIFKN SDGLGIKMPD PDFTVNDVKM CVGSRRMVDV MDVNTQKGIE MTMAQWTRYY ETPEEEREKL YNVISLEFSH TRLENMVQRP STVDFIDWVD NMWPRHLKES QTESTNAILE MQYPKVQKYC LMSVRGCYTD FHVDFGGTSV WYHIHQGGKV FWLIPPTAHN LELYENWLLS GKQGDIFLGD RVSDCQRIEL KQGYTFVIPS GWIHAVYTPT DTLVFGGNFL HSFNIPMQLK IYNIEDRTRV PNKFRYPFYY EMCWYVLERY VYCITNRSHL TKEFQKESLS MDLELNGLES GNGDEEAVDR EPRRLSSRRS VLTSPVANGV NLDYDGLGKT CRSLPSLKKT LAGDSSSDCS RGSHNGQVWD PQCAPRKDRQ VHLTHFELEG LRCLVDKLES LPLHKKCVPT GIEDEDALIA DVKILLEELA NSDPKLALTG VPIVQWPKRD KLKFPTRPKV RVPTIPITKP HTMKPAPRLT PVRPAAASPI VSGARRRRVR CRKCKACVQG ECGVCHYCRD MKKFGGPGRM KQSCVLRQCL APRLPHSVTC SLCGEVDQNE ETQDFEKKLM ECCICNEIVH PGCLQMDGEG LLNEELPNCW ECPKCYQEDS SEKAQKRKME ESDEEAVQAK VLRPLRSCDE PLTPPPHSPT SMLQLIHDPV SPRGMVTRSS PGAGPSDH

      • 予測される分子量

        115 kDa including tags

      • 領域

        1 to 748

    特性

    Our Abpromise guarantee covers the use of ab151923 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      Western blot

      SDS-PAGE

    • 製品の状態

      Liquid

    • 備考

       This product was previously labelled as FBXL11

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 7.50
      Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.004% EDTA, 25% Glycerol (glycerin, glycerine), 0.29% Sodium chloride

    関連情報

    • 別名

      • [Histone-H3]-lysine-36 demethylase 1A
      • CXXC-type zinc finger protein 8
      • CXXC8
      • F box / LRR repeat protein 11
      • F box and leucine rich repeat protein 11
      • F box protein FBL7
      • F-box and leucine-rich repeat protein 11
      • F-box protein FBL7
      • F-box protein Lilina
      • F-box/LRR-repeat protein 11
      • FBL11
      • FBL7
      • FBXL11
      • JHDM1A
      • JmjC domain-containing histone demethylation protein 1A
      • Jumonji C domain containing histone demethylase 1A
      • kdm2a
      • KDM2A_HUMAN
      • LILINA
      • Lysine (K) specific demethylase 2A
      • Lysine-specific demethylase 2A
      see all

    • 機能

      Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

    • 組織特異性

      Widely expressed, with highest levels in brain, testis and ovary, followed by lung.

    • 配列類似性

      Belongs to the JHDM1 histone demethylase family.
      Contains 1 CXXC-type zinc finger.
      Contains 1 F-box domain.
      Contains 1 JmjC domain.
      Contains 6 LRR (leucine-rich) repeats.
      Contains 1 PHD-type zinc finger.

    • ドメイン

      The JmjC domain mediates demethylation activity and is required for satellite silencing.
      The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated.

    • 翻訳後修飾

      Phosphorylated upon DNA damage, probably by ATM or ATR.

    • 細胞内局在

      Nucleus > nucleoplasm. Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human KDM2A protein (ab151923)
      SDS-PAGE - Recombinant Human KDM2A protein (ab151923)
      SDS-PAGE analysis of ab151923.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab151923 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab151923 は論文での使用が確認できていません。

    レビューと Q&A

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