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AB109850

Recombinant Human ITLN1 protein (denatured)

Recombinant Human ITLN1 protein (denatured)

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Recombinant Human ITLN1 protein (denatured) is a Human Full Length protein, in the 17 to 313 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

別名を表示する

INTL, ITLN, LFR, UNQ640/PRO1270, ITLN1, Intelectin-1, ITLN-1, Endothelial lectin HL-1, Galactofuranose-binding lectin, Intestinal lactoferrin receptor, Omentin

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SDS-PAGE - Recombinant Human ITLN1 protein (denatured) (AB109850)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ITLN1 protein (denatured) (AB109850)

15% SDS-PAGE (3 μg)

Key facts

精製度

>90% SDS-PAGE

発現系

Escherichia coli

タグ

Tag free

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

Q8WWA0

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.24% Urea

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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下記製品にもご興味をお持ちいただけるかもしれません:

AB269545

Human Omentin ELISA Kit (ITLN1)

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配列情報

[{"sequence":"MWSTDEANTYFKEWTCSSSPSLPRSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGSKAVYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLGHNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQCGDFSGFDWSGYGTHVGYSSSREITEAAVLLFYR","proteinLength":"Full Length","predictedMolecularWeight":"33.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":313,"aminoAcidStart":17,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WWA0","tags":[]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ITLN1 also known as 'omentin-1' or 'omentin' is a carbohydrate-binding protein mainly involved in the recognition and binding of microbial polysaccharides. This protein weighs approximately 36 kDa and is predominantly expressed in visceral fat and other tissues such as the heart lungs and placenta. ITLN1 functions as an adipokine a signaling molecule released by fat tissue and it plays a significant role in regulating glucose metabolism and insulin sensitivity.
Biological function summary

This target contributes to various important processes related to inflammatory and immune responses. ITLN1 is part of a complex network of interactions involving lectin receptors and other carbohydrate-binding proteins. It functions in response to pathogens by recognizing and trapping them thereby aiding in pathogen clearance. Its anti-inflammatory effects are mediated through its capacity to bind to ligands found on the surface of bacteria therefore preventing their adhesion and invasion.

Pathways

ITLN1 interacts with the insulin signaling and inflammation pathways. It has a direct relation with the PI3K/Akt pathway known to play roles in glucose uptake and metabolism. This interaction has a connection to proteins like insulin receptor substrate-1 (IRS-1) through this pathway. Additionally ITLN1 engages with adipocytokine pathways impacting processes like lipid metabolism and inflammation.

Researchers have found links between ITLN1 and metabolic diseases particularly type 2 diabetes and obesity. Reduced levels of ITLN1 correlate with poor metabolic control and increased risk for these conditions. Moreover its expression and secretion tend to alter in response to inflammation linking it with inflammatory disorders and processes. Other proteins such as adiponectin also involve themselves in these metabolic pathways providing insight into their interconnected roles in metabolic homeostasis.
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed : 11313366, PubMed : 26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed : 26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed : 26148048). Does not bind human glycans (PubMed : 26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed : 16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed : 16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed : 11747454, PubMed : 23921499).

翻訳後修飾

N-glycosylated.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed : 11313366, PubMed : 26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed : 26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed : 26148048). Does not bind human glycans (PubMed : 26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed : 16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed : 16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed : 11747454, PubMed : 23921499).
See full target information ITLN1
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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Product
Proteins & Peptides

AB157030

Recombinant Human ITLN1 protein

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recombinant-human-itln1-protein-ab157030

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(0 reviews)

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