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Recombinant Human IGFBP7 protein (ab50195)

Submit a review Q&A (2)References (1)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 98% SDS-PAGE
  • Endotoxin level: < 0.100 Eu/µg
  • Suitable for: SDS-PAGE

製品の詳細

  • 製品名

    Recombinant Human IGFBP7 protein
    IGFBP7 タンパク質・ペプチド 製品一覧

  • 精製度

    > 98 % SDS-PAGE.
    Greater than 98% by HPLC analyses. Endotoxin level is less than 0.1 ng per g (1EU/g).

  • エンドトキシン・レベル

    < 0.100 Eu/µg

  • 発現系

    Escherichia coli

  • アクセッション番号

    Q16270

  • タンパク質長

    Full length protein

  • Animal free

    No

  • 由来

    Recombinant

    • 生物種

      Human

    • 配列

      SSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGA GRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTT YPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQ VYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEK HEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKK GEGAEL

    • 予測される分子量

      26 kDa

    • 領域

      27 to 282

特性

Our Abpromise guarantee covers the use of ab50195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態

    Lyophilized
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

  • 再構成
    Reconstitute to 1mg/ml using sterile water.

関連情報

  • 別名

    • AGM
    • Angiomodulin
    • FSTL2
    • IBP-7
    • IBP7
    • IBP7_HUMAN
    • IGF binding protein 7
    • IGF-binding protein 7
    • IGFBP rP1
    • IGFBP-7
    • IGFBP-rP1
    • IGFBP7
    • IGFBPRP1
    • Insulin like growth factor binding protein 7
    • Insulin-like growth factor-binding protein 7
    • MAC25
    • MAC25 protein
    • PGI2 stimulating factor
    • PGI2-stimulating factor
    • Prostacyclin stimulating factor
    • Prostacyclin-stimulating factor
    • PSF
    • RAMSVPS
    • TAF
    • Tumor-derived adhesion factor
    see all

  • 機能

    Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

  • 配列類似性

    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 IGFBP N-terminal domain.
    Contains 1 Kazal-like domain.

  • 翻訳後修飾

    N-glycosylated.

  • 細胞内局在

    Secreted.
  • Information by UniProt

プロトコール

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

参考文献 (1)

ab50195 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab50195 は 1 報の論文で使用されています。

  • Li D  et al. Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis. Cell Death Discov 9:17 (2023). PubMed: 36681667

レビューと Q&A

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レビューを送る 質問を送る

1-2 of 2 Abreviews or Q&A

Question

Please confirm how to store this protein once it is reconstituted and how long will it be stable for.

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Answer

Thank you for your telephone enquiry this morning. As discussed on the telephone, this antibody can be reconstituted in sterile distilled water. If you include a carrier protein such as BSA, we recommend storing in working aliquots at -20oC for at least 3 months. If storing at 4oC, these can be kept for up to 1 week. I hope this will be helpful to you. Should you have any futher questions, please do not hesitate to contact us.

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Question

I am interested in the protein IGFBP7 for use in structural and functional studies however, the endogenous protein is glycolysated, and as you produce IGFBP7 in E. coli it is deglycolysated. I would like to know if the deglycolysated form wills behavior different from the glycolysated. Did you tried some functional test for this recombinant protein? Thanks,

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Answer

Thank you for your enquiry. With regards to our ab50195, we only make the non-glycosylated form of IGFBP7 and there is no information/data on glycolysated forms. Therefore, we are unable　to say whether the glycosylated version would act the same or not. If you decide to go ahead and purchase this product, we encourage you to submit an Abreview via the online product datasheet. We always encourage customers to send their results back to us, whether positive or negative, and we make all product information available to researchers. To find out more about our Abreview system, please see the following URL: https://www.abcam.com/abreviews I am sorry I can't be of more assistance in this occasion but should you have any other questions, please do not hesitate to contact me.

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