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AB173053

Recombinant Human IGF2BP2/IMP-2 protein

Recombinant Human IGF2BP2/IMP-2 protein

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(1 Publication)

Recombinant Human IGF2BP2/IMP-2 protein is a Human Fragment protein, in the 1 to 220 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

別名を表示する

IMP2, VICKZ2, IGF2BP2, Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2

1 Images
SDS-PAGE - Recombinant Human IGF2BP2/IMP-2 protein (AB173053)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human IGF2BP2/IMP-2 protein (AB173053)

SDS-PAGE analysis of Recombinant Human IGF2BP2 (ab173053).

Lane 1 + 2 : Recombinant Human IGF2BP2.
Lane 3 : Molecular weight markers.

Key facts

精製度

>95% SDS-PAGE

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

エンドトキシンレベル

< 1 EU/µg

発現系

Escherichia coli

タグ

His tag C-Terminus T7 tag N-Terminus

アプリケーション

SDS-PAGE, HPLC

applications

生物活性

No

アクセッション番号

Q9Y6M1

アニマルフリー

No

キャリアフリー

No

種

Human

再構成

Reconstitute in water

バッファー組成

pH: 7.4 Constituents: Phosphate Buffer, 0.877% Sodium chloride

storage-buffer

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組合せ製品

Primary Antibodies

AB124930

Anti-IGF2BP2/IMP-2 antibody [EPR6741(B)]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IGF2BP2/IMP-2 antibody [EPR6741(B)] (AB124930)

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  • 1
Proteins & Peptides

AB171480

Recombinant Human GAGE2D protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human GAGE2D protein (His tag N-Terminus) (AB171480)

  • 0
  • 0
Primary Antibodies

AB181142

Anti-PCSK9 antibody [EPR7627(2)]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-PCSK9 antibody [EPR7627(2)] (AB181142)

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  • 0
Primary Antibodies

AB177477

Anti-IMP3 antibody [EPR12021]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-IMP3 antibody [EPR12021] (AB177477)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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製品の詳細

Previously labelled as IGF2BP2.
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配列情報

[{"linker":null,"sequence":"MASMTGGQQMGRGSEFMMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITLEHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"27.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":220,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y6M1","tags":[{"tag":"His","terminus":"C-Terminus"},{"tag":"T7","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Lyophilized
出荷温度
Dry Ice
短期保存温度
-20°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
False
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一般的な情報

機能

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed : 29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed : 9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed : 29476152).

配列の類似性

Belongs to the RRM IMP/VICKZ family.

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製品プロトコール

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ターゲットの情報

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed : 29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed : 9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed : 29476152).
See full target information IGF2BP2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 11:680642 PubMed34386421

2021

Long Non-Coding RNA CCAT2 Promotes the Development of Esophageal Squamous Cell Carcinoma by Inhibiting miR-200b to Upregulate the IGF2BP2/TK1 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaodan Wu,Yihui Fan,Yupeng Liu,Biao Shen,Haimin Lu,Haitao Ma
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