AB101826

Recombinant Human Hsd17b11 protein (His tag N-Terminus)

Name: Recombinant Human Hsd17b11 protein (ab101826) | Abcam
Brand: Abcam Limited
SKU: AB101826
Price: 115000 JPY
Availability: InStock

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Recombinant Human Hsd17b11 protein (His tag N-Terminus) is a Human Fragment protein, in the 20 to 285 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

DHRS8, PAN1B, SDR16C2, PSEC0029, UNQ207/PRO233, HSD17B11, Estradiol 17-beta-dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase XI, Cutaneous T-cell lymphoma-associated antigen HD-CL-03, Dehydrogenase/reductase SDR family member 8, Retinal short-chain dehydrogenase/reductase 2, Short chain dehydrogenase/reductase family 16C member 2, 17-beta-HSD 11, 17bHSD11, 17betaHSD11, 17-beta-HSD XI, 17betaHSDXI, CTCL-associated antigen HD-CL-03, retSDR2

1 Images

SDS-PAGE - Recombinant Human Hsd17b11 protein (His tag N-Terminus) (AB101826)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Hsd17b11 protein (His tag N-Terminus) (AB101826)

15% SDS-PAGE analysis of 3μg ab101826

Key facts

精製度

>95% SDS-PAGE

発現系

Escherichia coli

アプリケーション

SDS-PAGE, Mass Spec

applications

生物活性

アクセッション番号

Q8NBQ5

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKI","proteinLength":"Fragment","predictedMolecularWeight":"31.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":285,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8NBQ5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Hsd17b11 also known as type 11 17-beta hydroxysteroid dehydrogenase is an enzyme that plays a role in steroid metabolism by catalyzing the conversion of less active 17-keto steroids to more active 17-beta-hydroxy steroids. The dehydrogenase weighs approximately 34 kDa and is found in various tissues but it is highly expressed in the liver and other steroidogenic tissues. As an NAD(P)-dependent oxidoreductase it contributes to maintaining steroid homeostasis within the cellular environment.

Biological function summary

Hsd17b11 influences steroidal balance by regulating the levels of active and inactive steroid hormones. It is sometimes associated with lipid metabolism processes but remains independent not a part of any known enzymatic complex. By controlling hormone levels Hsd17b11 impacts cellular functions related to metabolism growth and reproduction reinforcing its importance in maintaining proper physiological conditions.

Pathways

Hsd17b11 participates in steroid hormone metabolism and has roles within the broader steroidogenic pathway. It is related to the regulation of sex steroids closely working with enzymes like Hsd17b3 and Hsd17b2 which also modulate steroid hormones. These interactions contribute to comprehensive steroid biosynthesis and degradation pathways forming a network critical for endocrine system health.

Several studies have linked Hsd17b11 to disorders of steroid metabolism including polycystic ovary syndrome (PCOS) and some liver dysfunctions. Changes in its activity can affect steroid hormone levels perturbed in PCOS which often associates with aberrant androgen production. In metabolic liver disorders altered Hsd17b11 activity may disrupt lipid metabolism. The enzyme may also interact indirectly with proteins like SHBG (sex hormone-binding globulin) in these contexts influencing disease pathology and presentation.

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製品の性状

製品の状態

Liquid

補足情報

ab101826 was purified using conventional chromatography techniques.

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一般的な情報

機能

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

配列の類似性

Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information HSD17B11

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Abcam product promise

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Recombinant Human Hsd17b11 protein (His tag N-Terminus)