JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB132389

Recombinant Human HES6 protein (GST tag N-Terminus)

Recombinant Human HES6 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human HES6 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 224 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

別名を表示する

BHLHB41, HES6, Transcription cofactor HES-6, C-HAIRY1, Class B basic helix-loop-helix protein 41, Hairy and enhancer of split 6, bHLHb41

1 Images
SDS-PAGE - Recombinant Human HES6 protein (GST tag N-Terminus) (AB132389)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HES6 protein (GST tag N-Terminus) (AB132389)

ab132389 on 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

WB, ELISA, SDS-PAGE

applications

生物活性

No

アクセッション番号

Q96HZ4

アニマルフリー

No

キャリアフリー

No

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

配列情報

[{"sequence":"MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW","proteinLength":"Full Length","predictedMolecularWeight":"50.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":224,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96HZ4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

HES6 also known as Hairy and Enhancer of Split-6 is a protein involved in transcriptional regulation. It has a molecular mass of approximately 25 kilodaltons. Researchers find HES6 expression in multiple tissues including the brain muscle and pancreas. As a member of the bHLH (basic helix-loop-helix) transcription factor family HES6 negatively regulates transcription typically by antagonizing the activity of other transcription factors.
Biological function summary

HES6 influences cell differentiation and the timing of neurogenesis. It does not commonly act as part of a large complex but rather modulates activity by interacting directly with other transcription factors and regulatory proteins. Through these interactions HES6 helps control gene expression patterns important for the development of neural and muscular structures.

Pathways

HES6 participates in the Notch signaling pathway a critical mechanism for cell fate decisions. HES6 interacts with proteins such as HES1 and inhibition of some Notch pathway activities. This interaction influences cell differentiation processes particularly in the nervous system. Another pathway involving HES6 is the Wnt signaling pathway where it acts as a modulator in different cellular contexts though precise mechanical interactions within this pathway continue to be under investigation.

Researchers have associated HES6 with neurodegenerative diseases and muscle development disorders. In Alzheimer's disease for example dysregulation of the Notch pathway involving proteins such as HES1 and HES6 may contribute to pathogenesis. In muscular dystrophy alterations in the expression of HES6 could impact muscle repair and regeneration processes making it a target of interest for understanding and potentially treating such conditions.

製品の性状

製品の状態

Liquid

一般的な情報

機能

Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).

製品プロトコール

ターゲットの情報

Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
See full target information HES6

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com