AB168071

Recombinant Human HES2 protein (denatured)

Name: Recombinant Human HES2 protein (denatured) (ab168071) | Abcam
Brand: Abcam Limited
SKU: AB168071
Price: 88000 JPY
Availability: InStock

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(1 Publication)

Recombinant Human HES2 protein (denatured) is a Human Full Length protein, in the 1 to 173 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

別名を表示する

BHLHB40, HES2, Transcription factor HES-2, Class B basic helix-loop-helix protein 40, Hairy and enhancer of split 2, bHLHb40

1 Images

SDS-PAGE - Recombinant Human HES2 protein (denatured) (AB168071)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HES2 protein (denatured) (AB168071)

3 μg ab168071 on 15% SDS-PAGE

Key facts

精製度

>80% SDS-PAGE

発現系

Escherichia coli

アプリケーション

SDS-PAGE

applications

生物活性

アクセッション番号

Q9Y543

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW","proteinLength":"Full Length","predictedMolecularWeight":"20.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":173,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y543","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

HES2 short for Hairy and Enhancer of Split 2 is a basic helix-loop-helix (bHLH) transcriptional repressor. It belongs to the Hes family of genes known for their role in transcriptional regulation. HES2 weighs around 27 kiloDaltons. You can find HES2 expressed mainly in developing tissues such as embryonic stem cells and neural tissues where it plays an important role in cell fate decisions.

Biological function summary

HES2 functions as a transcriptional regulator by binding to specific DNA sequences. It plays an important role in maintaining the balance between proliferation and differentiation. HES2 acts as part of the Notch signaling pathway complex. This pathway is important in numerous developmental processes including the regulation of neurogenesis and myogenesis.

Pathways

HES2 actively participates in the Notch signaling pathway and interacts with other pathway components like HEY1 and DLL1. These interactions help regulate gene expression patterns necessary for stem cell maintenance and differentiation. It also contributes to the MAPK/ERK pathway facilitating various cellular processes such as cell survival and proliferation particularly through its interactions with E proteins.

HES2 has been linked to neurodegenerative disorders and certain cancers. Altered expression or mutations in HES2 can lead to developmental abnormalities contributing to conditions like glioblastoma. The target's dysregulation can affect Notch signaling thereby affecting proteins such as JAG1 and NOTCH1 which have known associations with these disorders.

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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Transcriptional repressor of genes that require a bHLH protein for their transcription.

細胞内局在性

Nucleus

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Transcriptional repressor of genes that require a bHLH protein for their transcription.

See full target information HES2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Oxidative medicine and cellular longevity 2022:7676872 PubMed36238644

2022

Lead Exposure Induced Neural Stem Cells Death via Notch Signaling Pathway and Gut-Brain Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Lijuan Sun,Yuankang Zou,Peng Su,Chong Xue,Diya Wang,Fang Zhao,Wenjing Luo,Jianbin Zhang

View all publications

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Abcam product promise

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Recombinant Human HES2 protein (denatured)