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AB63120

Recombinant Human Haptoglobulin beta protein

Recombinant Human Haptoglobulin beta protein

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Recombinant Human Haptoglobulin beta protein is a Human Full Length protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

別名を表示する

Haptoglobin, Zonulin, HP

1 Images
SDS-PAGE - Recombinant Human Haptoglobulin beta protein (AB63120)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Haptoglobulin beta protein (AB63120)

SDS page analysis of ab63120

Key facts

精製度

>95% SDS-PAGE

発現系

Escherichia coli

タグ

Tag free

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

P00738

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

Constituents: 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P00738","tags":[]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存温度
-20°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Haptoglobulin beta also known as Hp beta is a component of the haptoglobulin protein which binds free hemoglobin released from erythrocytes. This prevents oxidative damage to tissues. Haptoglobulin has a molecular mass of approximately 40 to 45 kDa depending on glycosylation. It is mainly expressed in the liver and then secreted into the bloodstream acting as an acute-phase protein during inflammatory responses.
Biological function summary

Haptoglobulin beta plays an important role in hemoglobin transport by forming a stable complex with free hemoglobin therefore facilitating its clearance by macrophages. This protein is a part of the haptoglobin-hemoglobin complex which is essential for preventing kidney damage and conserving iron after red blood cell lysis. Its biological function highlights its significance in the body's defense against oxidative stress.

Pathways

Haptoglobulin beta is involved in iron recycling and inflammation regulation. The hemoglobin scavenger receptor CD163 mediates the uptake of the haptoglobin-hemoglobin complex playing an important role in the iron metabolism pathway and immune system functioning. Additionally haptoglobulin is connected to the acute-phase response pathway alongside proteins like serum amyloid A to moderate inflammation and tissue protection.

Haptoglobulin beta links to hemolytic anemia and cardiovascular disease. A deficiency or polymorphism in the haptoglobulin gene can exacerbate complications in these conditions due to impaired hemoglobin scavenging. Heme released in absence of effective haptoglobulin activity promotes oxidative damage and inflammation contributing to disease pathology. C-reactive protein often interacts with haptoglobulin in the inflammatory network highlighting its multifaceted role in disease processes.
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

配列の類似性

Belongs to the peptidase S1 family.

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製品プロトコール

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ターゲットの情報

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
See full target information HP
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組合せ製品

Assay Kits

AB309180

Human Haptoglobin ELISA Kit

SimpleStep

ELISA - Human Haptoglobin ELISA Kit (AB309180)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB256454

Anti-Haptoglobin antibody [EPR22856-212]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Haptoglobin antibody [EPR22856-212] (AB256454)

  • 0
  • 0
Assay Kits

AB246539

Human MMP9 ELISA Kit

Recombinant|SimpleStep

ELISA - Human MMP9 ELISA Kit (AB246539)

  • 5
  • 1

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