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AB103052

Recombinant Human GRAP2 protein (His tag N-Terminus)

Recombinant Human GRAP2 protein (His tag N-Terminus)

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Recombinant Human GRAP2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 330 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

GADS, GRB2L, GRID, GRAP2, GRB2-related adapter protein 2, Adapter protein GRID, GRB-2-like protein, GRBLG, GRBX, Grf40 adapter protein, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, P38, Protein GADS, SH3-SH2-SH3 adapter Mona, Grf-40

1 Images
SDS-PAGE - Recombinant Human GRAP2 protein (His tag N-Terminus) (AB103052)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GRAP2 protein (His tag N-Terminus) (AB103052)

15% SDS-PAGE analysis of ab103052 (3μg)

Key facts

精製度

>90% SDS-PAGE

ab103052 was purified using conventional chromatography techniques.

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE, Mass Spec

applications

生物活性

No

アクセッション番号

O75791

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0292% EDTA

storage-buffer

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組合せ製品

Primary Antibodies

AB119244

Anti-GRAP2 antibody [OTI1G2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRAP2 antibody [OTI1G2] (AB119244)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR","proteinLength":"Full Length","predictedMolecularWeight":"40 kDa","actualMolecularWeight":null,"aminoAcidEnd":330,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75791","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
出荷温度
Blue Ice
短期保存温度
-20°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein GRAP2 also known as Gads plays an important role in intracellular signaling mechanisms. It is an adaptor protein with a mass of about 37 kDa. GRAP2 predominantly expresses in hematopoietic cells where it facilitates specific downstream signaling pathways. The protein assists in linking cell surface receptors to downstream signaling molecules enabling effective transmission of cellular signals.
Biological function summary

GRAP2 participates in the immune response by acting as a mediator that aids the assembly of signaling complexes. It often interacts with other proteins such as SLP-76 which is involved in specific immune cell activation. GRAP2 forms part of larger signaling complexes which are critical for the proper development and function of immune cells. This role highlights its importance in maintaining efficient immune surveillance and response.

Pathways

GRAP2 significantly contributes to the T-cell receptor (TCR) signaling pathway. It plays an integral part by interacting with proteins like LAT and ZAP-70 providing a scaffold for the further propagation of activation signals. Additionally in the Ras signaling pathway GRAP2 associates with other adaptor proteins coordinating downstream signaling needed for T cell activation and function.

GRAP2 has associations with immune system Pact conditions notably autoimmune diseases such as systemic lupus erythematosus (SLE). Its interactions with proteins like LAT and SLP-76 are important in these dysregulation of immune responses seen in these disorders. Any alteration in GRAP2 function or expression pathways could therefore potentially contribute to pathological immune activation reflecting its potential as a therapeutic target.
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一般的な情報

機能

Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

配列の類似性

Belongs to the GRB2/sem-5/DRK family.

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製品プロトコール

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ターゲットの情報

Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
See full target information GRAP2
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