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AB103054

Recombinant Human Grancalcin protein

Recombinant Human Grancalcin protein

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Recombinant Human Grancalcin protein is a Human Full Length protein, in the 1 to 217 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

GCL, GCA, Grancalcin

1 Images
SDS-PAGE - Recombinant Human Grancalcin protein (AB103054)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Grancalcin protein (AB103054)

SDS-PAGE of ab103054 (3µg) under reducing condition and visualized by coomassie blue stain.

Key facts

精製度

>95% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE, Mass Spec

applications

生物活性

No

アクセッション番号

P28676

アニマルフリー

No

キャリアフリー

No

Human

バッファー組成

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI","proteinLength":"Full Length","predictedMolecularWeight":"26.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":217,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P28676","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Grancalcin also known as GCL or GCA is a calcium-binding protein that belongs to the penta-EF-hand family. The protein has a molecular mass of about 24 kDa. It is predominantly found in neutrophils and monocytes where it localizes to the cytosol and cell membrane upon calcium activation. Grancalcin is known for its role in calcium signaling as its function is calcium-dependent which aids in modulating cellular processes.
Biological function summary

Grancalcin is involved in the regulation of cellular adhesion mechanisms. It does not form part of a larger protein complex but it plays a critical role in integrating calcium signals that facilitate cell function. Additionally grancalcin helps in the reorganization of the cytoskeleton impacting processes like chemotaxis and phagocytosis important for immune response.

Pathways

Grancalcin plays a role in the integrin signaling pathway. It interacts with key proteins in this pathway such as talin and vinculin to mediate cell adhesion and motility. Grancalcin's regulation of calcium signals also ties it to the MAPK signaling pathway which influences various cell functions including proliferation and differentiation.

Alterations in grancalcin expression or function have connections to immune-related diseases such as chronic inflammation. Aberrant levels may also have implications in cancer metastasis where cell adhesion and motility affect tumor spread. Grancalcin's role in these conditions may involve interactions with integrin-associated proteins that modulate the mechanical properties of cells.

製品の性状

製品の状態

Liquid

補足情報

ab103054 was purified using conventional chromatography.

一般的な情報

機能

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.

製品プロトコール

ターゲットの情報

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.
See full target information GCA

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