AB314629

Recombinant Human GPR157 Protein (His Tag)

Name: Recombinant Human GPR157 Protein (His Tag) (ab314629) | Abcam
Brand: Abcam Limited
SKU: AB314629
Price: 362000 JPY
Availability: InStock

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Recombinant Human GPR157 Protein (His Tag) is a Human Full Length protein, in the 1 to 335 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

別名を表示する

G-protein coupled receptor 157, GPR157

1 Images

SDS-PAGE - Recombinant Human GPR157 Protein (His Tag) (AB314629)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GPR157 Protein (His Tag) (AB314629)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

精製度

>85% SDS-PAGE

発現系

Escherichia coli

アプリケーション

SDS-PAGE

applications

生物活性

アクセッション番号

Q5UAW9

アニマルフリー

Yes

キャリアフリー

種

Human

再構成

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

バッファー組成

pH: 7.4 - 8 Constituents: PBS, 6% Trehalose

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"linker":null,"sequence":"MQPSPPPTELVPSERAVVLLSCALSALGSGLLVATHALWPDLRSRARRLLLFLSLADLLSAASYFYGVLQNFAGPSWDCVLQGALSTFANTSSFFWTVAIALYLYLSIVRAARGPRTDRLLWAFHVVSWGVPLVITVAAVALKKIGYDASDVSVGWCWIDLEAKDHVLWMLLTGKLWEMLAYVLLPLLYLLVRKHINRAHTALSEYRPILSQEHRLLRHSSMADKKLVLIPLIFIGLRVWSTVRFVLTLCGSPAVQTPVLVVLHGIGNTFQGGANCIMFVLCTRAVRTRLFSLCCCCCSSQPPTKSPAGTPKAPAPSKPGESQESQGTPGELPST","proteinLength":"Full Length","predictedMolecularWeight":"39.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":335,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q5UAW9","tags":[{"tag":"10x His","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

製品の状態

Lyophilized

精製方法

Ion exchange chromatography

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-80°C

分注に関する情報

Add glycerol to a final volume of 50% for extra stability and aliquot

保管に関する情報

The product can be stored for up to 12 months

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

G protein-coupled receptor 157 also known as GPR157 is a member of the GPCR family involved in cell signaling. This protein has a significant role in signal transmission across cell membranes. The molecular mass of GPR157 is approximately 38 kDa. GPR157 is expressed in a variety of tissues with notable expression within the brain indicating its involvement in neurological processes.

Biological function summary

GPR157 influences various processes by modulating intracellular signaling pathways. It participates in forming complexes with other cellular proteins contributing to significant biological activities. The protein is known for its role in neural development and function. It interacts with other receptors and signaling molecules within the cell to regulate brain-related mechanisms showing its importance in neurobiology.

Pathways

GPR157 plays a critical role in the Wnt signaling pathway and the neurotrophic factor-mediated pathway. Through these pathways GPR157 interacts with other proteins like β-catenin and TrkB which are important for signal transduction related to cell growth and survival. This involvement highlights its significance in maintaining normal cellular processes and preventing abnormal signaling.

GPR157 has implications in neurological conditions and psychiatric disorders notably schizophrenia and neurodegenerative diseases. There are associations between GPR157 and dysregulated signaling processes involving proteins like dopamine receptors which could lead to improper brain functioning. Studying GPR157 provides insights into potential therapeutic targets for these conditions.

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一般的な情報

機能

Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.

配列の類似性

Belongs to the G-protein coupled receptor 2 family.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information human G-protein coupled receptor 157

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Abcam product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Recombinant Human GPR157 Protein (His Tag)