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AB152435

Recombinant Human GPCR GPR39 protein (GST tag N-Terminus)

Recombinant Human GPCR GPR39 protein (GST tag N-Terminus)

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Recombinant Human GPCR GPR39 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 453 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

別名を表示する

G-protein coupled receptor 39, GPR39

1 Images
SDS-PAGE - Recombinant Human GPCR GPR39 protein (GST tag N-Terminus) (AB152435)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPCR GPR39 protein (GST tag N-Terminus) (AB152435)

12.5% SDS-PAGE analysis of ab152435 stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

ELISA, WB, SDS-PAGE

applications

生物活性

No

アクセッション番号

O43194

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV","proteinLength":"Full Length","predictedMolecularWeight":"77.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":453,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O43194","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

GPR39 also known as G-protein coupled receptor 39 is a member of the G-protein coupled receptor (GPCR) family which play important roles in signaling mechanisms in cells. This receptor has a mass of approximately 53 kDa. It is expressed in multiple human tissues with a significant presence in the gastrointestinal tract kidney and pancreas. GPR39 is involved in binding zinc ions which suggests a regulatory role under physiological conditions where zinc concentrations fluctuate.
Biological function summary

GPR39 influences various physiological processes related to metabolic and homeostatic functions in the body. It is not part of a complex but operates as a standalone receptor that activates diverse intracellular pathways upon ligand binding. The receptor has reported roles in regulating appetite influencing glucose metabolism and maintaining energy balance. Through the modulation of different cellular signals GPR39 helps in controlling processes like gastric acid secretion and insulin sensitivity.

Pathways

Researchers recognize GPR39’s involvement in the Wnt signaling and mTOR signaling pathways. In the context of the Wnt pathway GPR39 interfaces through interactions with other signaling molecules and proteins like beta-catenin which underpins its role in cellular growth and differentiation. Meanwhile in the mTOR pathway its interaction influences protein synthesis and cellular metabolism. These pathways highlight the receptor's pivotal role in various biological processes.

GPR39's functional implications extend to conditions such as metabolic syndrome and gastrointestinal disorders. Its regulation of metabolic processes links it to metabolic syndrome where insulin resistance and glucose homeostasis are disrupted. Additionally in gastrointestinal disorders changes in its expression or function relate to conditions like irritable bowel syndrome (IBS). Interactions with proteins such as ghrelin and insulin highlight its extensive influence as these proteins are essential for metabolic and appetite regulation.
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed : 18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed : 20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed : 18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity : HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed : 26365466).

配列の類似性

Belongs to the G-protein coupled receptor 1 family.

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製品プロトコール

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ターゲットの情報

Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed : 18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed : 20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed : 18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity : HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed : 26365466).
See full target information GPR39
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組合せ製品

Reagents, Controls & Accessories

AB325997

Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color) (AB325997)

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Proteins & Peptides

AB116876

Recombinant Human GPCR GPR12 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human GPCR GPR12 protein (GST tag N-Terminus) (AB116876)

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Proteins & Peptides

AB289775

Recombinant Mouse GPCR GPR146 protein

SDS-PAGE - Recombinant Mouse GPCR GPR146 protein (AB289775)

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Proteins & Peptides

AB164813

Recombinant Human UCN2/SRP protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human UCN2/SRP protein (GST tag N-Terminus) (AB164813)

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Primary Antibodies

AB229648

Anti-GPCR GPR39 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR39 antibody - C-terminal (AB229648)

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