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AB116876

Recombinant Human GPCR GPR12 protein (GST tag N-Terminus)

Recombinant Human GPCR GPR12 protein (GST tag N-Terminus)

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Recombinant Human GPCR GPR12 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 334 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

別名を表示する

G-protein coupled receptor 12, GPR12

1 Images
SDS-PAGE - Recombinant Human GPCR GPR12 protein (GST tag N-Terminus) (AB116876)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPCR GPR12 protein (GST tag N-Terminus) (AB116876)

12.5% SDS-PAGE showing ab116876 at approximately 62.81kDa stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

ELISA, WB, SDS-PAGE

applications

生物活性

No

アクセッション番号

P47775

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Recombinant protein.</p>" } } }
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配列情報

[{"sequence":"MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV","proteinLength":"Full Length","predictedMolecularWeight":"62.81 kDa","actualMolecularWeight":null,"aminoAcidEnd":334,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P47775","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

GPCR GPR12 also known as G-protein coupled receptor 12 is a member of the GPCR family which controls many physiological processes by transmitting signals across the cell membrane. It consists of around 370 amino acids giving it an approximate mass of 42 kDa. GPR12 is expressed in the central nervous system particularly in the brain with some expression noted in peripheral tissues such as the testes. The receptor activates several G proteins upon stimulation by ligands influencing a variety of downstream cellular responses.
Biological function summary

GPR12 influences cellular processes related to neurodevelopment and neuronal differentiation. It contributes to the regulation of neuronal growth offering support to synaptic connectivity and plasticity. This receptor may operate as part of a signaling complex although its specific complex partners remain unspecified. Its activity promotes cell survival pathways indicating its broader role in maintaining proper function of neural cells.

Pathways

Some cells utilize GPR12 within the lipid signaling and neurotrophic pathways. GPR12 interacts with cyclic adenosine monophosphate (cAMP) as part of the lipid signaling pathway influencing cellular metabolism and growth. Another critical interaction involves its cross-talk with neurotrophic factors like brain-derived neurotrophic factor (BDNF) highlighting its relevance in neural health and responsiveness to environmental changes.

Research links GPR12 to neurological conditions such as Alzheimer's disease and mood disorders. Its dysregulation affects synaptic function and may exacerbate neurodegenerative processes in Alzheimer's. Moreover GPR12 interacts with proteins like amyloid precursor protein (APP) in the context of Alzheimer's pathology. Abnormal expression of GPR12 might also disrupt mood regulation connecting it to proteins like serotonin receptors linking to mood disorders.
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.

配列の類似性

Belongs to the G-protein coupled receptor 1 family.

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製品プロトコール

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ターゲットの情報

Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.
See full target information GPR12
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