AB153211

Recombinant Human GP210 protein

Name: Recombinant Human GP210 protein (ab153211) | Abcam
Brand: Abcam Limited
SKU: AB153211
Price: 118000 JPY
Availability: InStock

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Recombinant Human GP210 protein is a Human Full Length protein, in the 1 to 967 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

KIAA0906, PSEC0245, NUP210, Nuclear pore membrane glycoprotein 210, Nuclear pore protein gp210, Nuclear envelope pore membrane protein POM 210, Nucleoporin Nup210, Pore membrane protein of 210 kDa, POM210

1 Images

SDS-PAGE - Recombinant Human GP210 protein (AB153211)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GP210 protein (AB153211)

ab153211 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

アプリケーション

ELISA, WB

applications

生物活性

アクセッション番号

Q8TEM1

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"MAARGRGLLLLTLSVLLAAGPSAAAAKLNIPKVLLPFTRATRVNFTLEASEGCYRWLSTRPEVASIEPLGLDEQQCSQKAVVQARLTQPARLTSIIFAEDITTGQVLRCDAIVDLIHDIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFEWTIVKDSEADRFSDSHNALRILTFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLMVGTSIHYKVQKIRQGKITELSMPSDQYELQLQNSIPGPEGDPARPVAVLAQDTSMVTALQLGQSSLVLGHRSIRMQGASRLPNSTIYVVEPGYLGFTVHPGDRWVLETGRLYEITIEVFDKFSNKVYVSDNIRIETVLPAEFFEVLSSSQNGSYHRIRALKRGQTAIDAALTSVVDQDGGVHILQVPVWNQQEVEIHIPITLYPSILTFPWQPKTGAYQYTIRAHGGSGNFSWSSSSHLVATVTVKGVMTTGSDIGFSVIQAHDVQNPLHFGEMKVYVIEPHSMEFAPCQVEARVGQALELPLRISGLMPGGASEVVTLSDCSHFDLAVEVENQGVFQPLPGRLPPGSEHCSGIRVKAEAQGSTTLLVSYRHGHVHLSAKITIAAYLPLKAVDPSSVALVTLGSSKEMLFEGGPRPWILEPSKFFQNVTAEDTDSIGLALFAPHSSRNYQQHWILVTCQALGEQVIALSVGNKPSLTNPFPAVEPAVVKFVCAPPSRLTLAPVYTSPQLDMSCPLLQQNKQVVPVSSHRNPRLDLAAYDQEGRRFDNFSSLSIQWESTRPVLASIEPELPMQLVSQDDESGQKKLHGLQAILVHEASGTTAITATATGYQESHLSSARTKQPHDPLVPLSASIELILVEDVRVSPEEVTIYNHPGIQAELRIREGSGYFFLNTSTADVVKVAYQEARGVAMVSLGHRSPLLVFIPYLGCCVVN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":967,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8TEM1","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Dry Ice

短期保存温度

-80°C

長期保存温度

-80°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

GP210 also known as Nup210 is a critical component of the nuclear pore complex with a molecular mass of approximately 210 kDa. This integral membrane protein is primarily expressed in the nuclear envelope of eukaryotic cells. GP210 plays a significant mechanical role in the structural integrity of the nuclear pore complex a pivotal gateway for nucleocytoplasmic transport. Its localization at the nuclear envelope suggests its importance in maintaining the selective barrier and facilitating transport functions between the nucleus and the cytoplasm.

Biological function summary

GP210 is involved in the regulation of nuclear-cytoplasmic transport and acts as a scaffold for various transport machinery components. As a member of the nuclear pore complex it interacts with other nucleoporins forming a channel that allows the passage of molecules between the nucleus and cytoplasm. GP210 participates in processes related to genome regulation influencing gene expression by modulating nuclear import/export cycles. Alterations in GP210 function can have implications for the cell cycle and differentiation processes.

Pathways

GP210 engages in the nucleocytoplasmic transport pathway which is essential for the transport of macromolecules such as RNA and proteins. This pathway is closely related to the Ran GTPase cycle where GP210 plays a supporting role in maintaining the directionality of the transport. It interacts with transport factors such as importins and exportins ensuring the precise regulation of molecular traffic. GP210's involvement ties it to key cellular functions and highlights its critical role in cellular homeostasis and signal transduction.

Aberrant function or expression of GP210 has been implicated in autoimmune diseases such as primary biliary cholangitis (PBC). Autoantibodies against GP210 are often detected in patients with PBC indicating its role in the pathogenesis of this autoimmune liver disorder. Furthermore GP210 is associated with certain cancer types where its dysregulation might contribute to tumorigenesis and cancer progression. In these contexts GP210 could interact with oncogenic or tumor suppressor proteins highlighting its potential as a biomarker and target for therapeutic intervention.

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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

配列の類似性

Belongs to the NUP210 family.

翻訳後修飾

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).. Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.

細胞内局在性

Nucleus

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製品プロトコール

Visit the General protocols
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ターゲットの情報

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

See full target information NUP210

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Abcam product promise

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Recombinant Human GP210 protein