AB116188

Recombinant Human GAS41 protein (His tag N-Terminus)

Name: Recombinant Human GAS41 protein (ab116188) | Abcam
Brand: Abcam Limited
SKU: AB116188
Price: 118000 JPY
Availability: InStock

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Recombinant Human GAS41 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 227 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

GAS41, YEATS4, YEATS domain-containing protein 4, Glioma-amplified sequence 41, NuMA-binding protein 1, Gas41, NuBI-1, NuBI1

1 Images

SDS-PAGE - Recombinant Human GAS41 protein (AB116188)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GAS41 protein (AB116188)

ab116188 (3μg) analysed on a 15% SDS-PAGE gel.

Key facts

精製度

>90% SDS-PAGE

発現系

Escherichia coli

アプリケーション

SDS-PAGE, Mass Spec

applications

生物活性

アクセッション番号

O95619

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 7.5 Constituents: 30% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQAKDI","proteinLength":"Full Length","predictedMolecularWeight":"28.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":227,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O95619","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein GAS41 also known as Glioma-Amplified Sequence 41 weighs approximately 26 kDa. It is ubiquitously expressed in various cell types including brain and neuronal tissues. GAS41 performs as a component of the chromatin remodeling complex. This protein participates in DNA binding and potentially regulates transcription processes influencing gene expression patterns.

Biological function summary

GAS41 impacts cellular proliferation and organization. It is often part of the Tip60/NuA4 histone acetyltransferase complex which is involved in chromatin modification. Through its role in this complex GAS41 influences transcriptional regulation by modifying chromatin architecture. This process ultimately affects how genes are turned on or off in cells which is key for maintaining cellular function and identity.

Pathways

GAS41 plays a significant role in the regulation of gene expression pathways and cell cycle control. It interacts with proteins in the SWI/SNF-related chromatin remodeler pathways and modulates how genes involved in cell cycle progression are expressed. GAS41 shows interaction with proteins like p400 which also contributes to these pathways indicating its importance in cellular growth and division.

GAS41 is linked to glioma progression and certain neurodegenerative disorders. Changes in the expression of GAS41 have been observed in gliomas connecting it with the uncontrolled cell growth characteristic of these tumors. Through its association with other proteins like ATRX GAS41 is implicated in chromatin remodeling disturbances seen in neurodegenerative diseases influencing gene expression patterns and contributing to disease pathogenesis.

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製品の性状

製品の状態

Liquid

補足情報

ab116188 was purified using conventional chromatography.

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一般的な情報

機能

Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed : 12963728, PubMed : 14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed : 29437725, PubMed : 29900004, PubMed : 30071723). Also able to recognize and bind crotonylated histone H3 (PubMed : 30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed : 29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions : recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed : 29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity).

細胞内局在性

Nucleus

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information YEATS4

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Abcam product promise

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Recombinant Human GAS41 protein (His tag N-Terminus)