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Recombinant Human FUNDC1 protein (ab165435)

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SDS-PAGE - Recombinant Human FUNDC1 protein (ab165435)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    製品の詳細

    • 製品名

      Recombinant Human FUNDC1 protein

    • 発現系

      Wheat germ

    • タンパク質長

      Full length protein

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MATRNPPPQDYESDDDSYEVLDLTEYARRHQWWNRVFGHSSGPMVEKYSV ATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQIDWK RVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNIVISSGFVGGFL LGLAS

      • 領域

        1 to 155

      • タグ

        GST tag N-Terminus

    特性

    Our Abpromise guarantee covers the use of ab165435 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      ELISA

      Western blot

    • 製品の状態

      Liquid

    • 備考

       

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    関連情報

    • 別名

      • FUN14 domain containing 1
      • FUN14 domain containing protein 1
      • FUN14 domain-containing protein 1
      • FUND1_HUMAN
      • fundc1
      see all

    • 機能

      Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.

    • 組織特異性

      Widely expressed.

    • 配列類似性

      Belongs to the FUN14 family.

    • ドメイン

      The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP (PubMed:22267086).

    • 翻訳後修飾

      Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy.

    • 細胞内局在

      Mitochondrion outer membrane.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human FUNDC1 protein (ab165435)
      SDS-PAGE - Recombinant Human FUNDC1 protein (ab165435)
      ab165435 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab165435 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab165435 は論文での使用が確認できていません。

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