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Recombinant Human Fbxw7 protein (ab289752)

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SDS-PAGE - Recombinant Human Fbxw7 protein (ab289752)

    Key features and details

    • Expression system: Cell free
    • Purity: >= 90% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE

    製品の詳細

    • 製品名

      Recombinant Human Fbxw7 protein
      Fbxw7 タンパク質・ペプチド 製品一覧

    • 精製度

      >= 90 % SDS-PAGE.

    • 発現系

      Cell free

    • アクセッション番号

      Q969H0

    • タンパク質長

      Full length protein

    • Animal free

      Yes

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ ESDDFDQSDD SSREDEHTHT NSVTNSSSIV DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL DFDVDMK

      • 予測される分子量

        84 kDa including tags

      • 領域

        1 to 707

      • タグ

        His tag N-Terminus

      • 配列の追加情報

        6xHis

    特性

    Our Abpromise guarantee covers the use of ab289752 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      SDS-PAGE

    • 製品の状態

      Lyophilized
    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 7.40
      Constituents: 0.14% Dibasic monohydrogen sodium phosphate, 0.79% Sodium chloride, 0.02% Potassium chloride, 0.024% Monobasic dihydrogen potassium phosphate, 6% Trehalose

    関連情報

    • 別名

      • AGO
      • Archipelago
      • Archipelago homolog
      • Archipelago, Drosophila, homolog of
      • CDC4
      • CDC4, S.cerevisiae, homolog of
      • DKFZp686F23254
      • F box and WD 40 domain protein 7
      • F box and WD 40 domain protein 7 (archipelago homolog, Drosophila)
      • F box and WD repeat domain containing 7
      • F box protein FBW7
      • F box protein FBX30
      • F box protein SEL 10
      • F box protein SEL10
      • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
      • F-box and WD-40 domain-containing protein 7
      • F-box protein FBX30
      • F-box/WD repeat-containing protein 7
      • FBW6
      • FBW7
      • FBX30
      • FBXO30
      • FBXW6
      • FBXW7
      • FBXW7_HUMAN
      • FLJ16457
      • hAgo
      • hCdc4
      • Homolog of C elegans sel 10
      • Homolog of C.elegans sel10
      • SEL 10
      • SEL-10
      • SEL10
      see all

    • 機能

      Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.

    • 組織特異性

      Isoform 1 is widely expressed. Isoform 4 is expressed in brain.

    • 配列類似性

      Contains 1 F-box domain.
      Contains 7 WD repeats.

    • 翻訳後修飾

      Phosphorylated upon DNA damage, probably by ATM or ATR.

    • 細胞内局在

      Cytoplasm; Nucleus; Nucleus > nucleolus and Nucleus > nucleoplasm.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human Fbxw7 protein (ab289752)
      SDS-PAGE - Recombinant Human Fbxw7 protein (ab289752)
      SDS-PAGE analysis of ab289752

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab289752 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab289752 は論文での使用が確認できていません。

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