JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB174554

Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus)

Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 213 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

別名を表示する

FAIM1, FAIM, Fas apoptotic inhibitory molecule 1

1 Images
SDS-PAGE - Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) (AB174554)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) (AB174554)

15% SDS-PAGE analysis of ab174554 (3 μg).

Key facts

精製度

>85% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

Q9NVQ4

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

style
left-column

組合せ製品

Primary Antibodies

AB215191

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

  • 5
  • 4
Proteins & Peptides

AB164800

Recombinant Human TMEM116 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human TMEM116 protein (GST tag N-Terminus) (AB164800)

  • 0
  • 0
Primary Antibodies

AB184787

Anti-Caspase-3 antibody [EPR18297]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-3 antibody [EPR18297] (AB184787)

  • 3
  • 3
Primary Antibodies

AB209845

Anti-GSDMD antibody [EPR19828]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-GSDMD antibody [EPR19828] (AB209845)

  • 4
  • 3
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

配列情報

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLLPFIRTLPLLCYNHLLVSPDSATLSPPYSLEKMTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGAAKTKATINIDAISGFAYEYTLEINGKSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGIIHTLIVDNREIPEIAS","proteinLength":"Full Length","predictedMolecularWeight":"26.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":213,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NVQ4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

FAIM1 also known as Fas Apoptotic Inhibitory Molecule 1 inhibits apoptosis. This protein has a molecular mass of approximately 24 kDa and comes from expression in various tissues with significant presence in the brain liver and immune cells. FAIM1 blocks apoptotic signals triggered via the Fas receptor also called CD95 ensuring cell survival under certain challenging conditions.
Biological function summary

Functions of FAIM1 support anti-apoptotic activities independent of death receptor pathways. It participates in cellular responses to stress like oxidative stress. The protein does not seem to form a complex but interacts with proteins involved in cell death regulation such as Fas-associated proteins to modulate stress response and survival signaling pathways.

Pathways

FAIM1 shows involvement in apoptosis-related pathways and affects the NF-κB signaling. The protein acts in the molecular framework by inhibiting signals from the Fas receptor collaborating with proteins such as FLIP which also regulate cell death pathways. FAIM1 further influences signaling through NF-κB essential in modulating the immune response.

Research links FAIM1 to neurodegenerative diseases like Alzheimer's disease due to its protective effects against apoptotic cell death. Connections exist between FAIM1 and increased cell survival involving proteins like Bcl-xL which enhance the survival of neurons in stressful environments. FAIM1 also associates with cancer where its overexpression could relate to increased tumor cell survival detailing interactions with oncogenic pathways.
style
left-column

一般的な情報

機能

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

配列の類似性

Belongs to the FAIM1 family.

style
left-column

製品プロトコール

style
left-column

ターゲットの情報

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.
See full target information FAIM
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com