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AB219452

Recombinant Human Ephrin B3 protein (His tag C-Terminus)

Recombinant Human Ephrin B3 protein (His tag C-Terminus)

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Recombinant Human Ephrin B3 protein (His tag C-Terminus) is a Human Fragment protein, in the 28 to 226 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

別名を表示する

EPLG8, LERK8, EFNB3, Ephrin-B3, EPH-related receptor transmembrane ligand ELK-L3, EPH-related receptor tyrosine kinase ligand 8, LERK-8

1 Images
SDS-PAGE - Recombinant Human Ephrin B3 protein (His tag C-Terminus) (AB219452)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Ephrin B3 protein (His tag C-Terminus) (AB219452)

15% SDS-PAGE using 3ug of ab219452.

Key facts

精製度

>95% SDS-PAGE

Affinity purified

エンドトキシンレベル

< 1 EU/µg

発現系

Baculovirus infected insect cells

タグ

His tag C-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

Q15768

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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組合せ製品

Reagents, Controls & Accessories

AB133411

Low Fluorescence Western Membrane (PVDF)

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Proteins & Peptides

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Recombinant AMARV GP protein (His tag)

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Primary Antibodies

AB52894

Anti-EGFR antibody [EP38Y]

BOND RX™ Validated|KO Validated|RabMAb|Lab Essentials|20ul selling size|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFR antibody [EP38Y] (AB52894)

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Proteins & Peptides

AB191954

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Proteins & Peptides

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Recombinant EN-TEV Protease protein

Bioactive

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"ADPLSLEPVYWNSANKRFQAEGGYVLYPQIGDRLDLLCPRARPPGPHSSPNYEFYKLYLVGGAQGRRCEAPPAPNLLLTCDRPDLDLRFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQGGVCLTRGMKVLLRVGQSPRGGAVPRKPVSEMPMERDRGAAHSLEPGKENLPGDPTSNATSRGAEGPLPPPSMPHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"23 kDa","actualMolecularWeight":null,"aminoAcidEnd":226,"aminoAcidStart":28,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q15768","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Ephrin B3 also known as EFNB3 is a critical membrane-bound ligand for the Eph receptor tyrosine kinases. EFNB3 belongs to the ephrin family with a molecular mass of approximately 37 kDa. It predominantly expresses in the brain although researchers have detected it in other tissues as well. The protein plays a significant role in various cellular processes such as cell adhesion shape and migration.
Biological function summary

EFNB3 influences axon guidance and neural development. As part of a receptor-ligand complex it interacts with Eph receptors to regulate synaptic plasticity which is essential for learning and memory. This interaction also plays a role in mediating repulsive and attractive signals that guide neurons during developmental processes. EFNB3 exhibits distinct binding characteristics which determine specific cellular responses.

Pathways

EFNB3 influences both the ephrin signaling pathway and the nervous system development pathway. It engages with Eph receptors particularly EphB3 and EphA4 to trigger downstream signaling cascades that influence cellular structure and fate. The Eph-ephrin pathways are important in neurodevelopmental processes assisting in the formation of spatially regulated cell organization.

EFNB3 has connections to neurodegenerative diseases and cancer. Abnormal EFNB3 signaling can contribute to Alzheimer's Disease due to its role in neuronal connectivity and communication. The protein also associates with glioblastoma as it can influence tumor cell invasiveness and growth. Changes in ephrin signaling can alter normal cellular behavior which may progress to various pathological conditions.
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一般的な情報

機能

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).. (Microbial infection) Acts as a receptor for nipah virus and hendra virus.

配列の類似性

Belongs to the ephrin family.

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製品プロトコール

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ターゲットの情報

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).. (Microbial infection) Acts as a receptor for nipah virus and hendra virus.
See full target information EFNB3
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