Recombinant Human ENSA protein (ab92932)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Suitable for: SDS-PAGE
製品の詳細
-
製品名
Recombinant Human ENSA protein -
精製度
> 90 % SDS-PAGE.
ab92932 is purified using conventional chromatography techniques. -
発現系
Escherichia coli -
タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
-
生物種
Human -
配列
MGSSHHHHHH SSGLVPRGSH MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV E
-
関連製品
-
Related Products
特性
Our Abpromise guarantee covers the use of ab92932 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
アプリケーション
SDS-PAGE
-
製品の状態
Liquid -
Concentration information loading...
前処理および保存
-
保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 8.00
Constituents: 0.0154% DTT, 0.316% Tris HCl, 10% Glycerol
関連情報
-
別名
- Alpha endosulfine
- Alpha-endosulfine
- ARPP 19e
see all -
機能
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. -
組織特異性
Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. -
配列類似性
Belongs to the endosulfine family. -
翻訳後修飾
Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA. -
細胞内局在
Cytoplasm. - Information by UniProt
画像
-
SDS-PAGE - Recombinant Human ENSA protein (ab92932)ab92932 staining ENSA protein on a 15% SDS-PAGE (3 µg)
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (2)
ab92932 は 2 報の論文で使用されています。
- Watamura N et al. Somatostatin-evoked Aß catabolism in the brain: Mechanistic involvement of a-endosulfine-KATP channel pathway. Mol Psychiatry 27:1816-1828 (2022). PubMed: 34737456
- Marzec KA et al. SILAC kinase screen identifies potential MASTL substrates. Sci Rep 12:10568 (2022). PubMed: 35732702