AB235678

Recombinant Human ENOX2/tNOX protein (Tagged)

Name: Recombinant Human ENOX2/tNOX protein (Tagged) (ab235678) | Abcam
Brand: Abcam Limited
SKU: AB235678
Price: 173000 JPY
Availability: InStock

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Recombinant Human ENOX2/tNOX protein (Tagged) is a Human Full Length protein, in the 1 to 610 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

別名を表示する

COVA1, ENOX2, Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX

1 Images

SDS-PAGE - Recombinant Human ENOX2/tNOX protein (Tagged) (AB235678)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ENOX2/tNOX protein (Tagged) (AB235678)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel of ab235678.

Key facts

精製度

>85% SDS-PAGE

発現系

Escherichia coli

アプリケーション

SDS-PAGE

applications

生物活性

アクセッション番号

Q16206

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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製品の詳細

Previously labelled as ENOX2.

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配列情報

[{"sequence":"MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT","proteinLength":"Full Length","predictedMolecularWeight":"77.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":610,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16206","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存温度

-20°C

長期保存温度

-20°C

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ENOX2 also known as tumor-associated NADH oxidase or tNOX is a protein involved in cellular processes including growth and apoptosis. It has a molecular mass of approximately 46 kDa and exhibits unique activity patterns cycling with a 24-minute period. ENOX2 is expressed mostly in cancer cells but not in normal cells which makes it a potential biomarker for various types of cancer. This expression pattern offers a significant advantage for targeted cancer therapies focusing efforts on treating malignant cells while sparing healthy tissues.

Biological function summary

This enzyme plays a role in electron transport and cell surface NADH oxidase activity. ENOX2 forms part of a complex involved in the regulation of cellular energy and growth directly impacting cellular proliferation rates. It contributes to the maintenance of extracellular environments that support cancer cell survival and proliferation. Its activity parallels growth rates in cancer cells further implicating its function in tumorigenesis and oncogenic processes.

Pathways

ENOX2 operates within the NADH/NAD+ redox system and impacts the pathways that govern cellular metabolism and energy flow. It interacts with proteins in the oxidative phosphorylation pathway which is critical for ATP production and cellular energy regulation. ENOX2 links to proteins such as cytochrome c oxidase and its influence extends to pathways associated with glycolytic processes and mitochondrial function illustrating its central part in metabolic reprogramming in cancer cells.

ENOX2 is strongly associated with cancer serving as both a diagnostic marker and a potential therapeutic target. Its cancer-specific expression pattern exposes its linkage to oncogenic pathways. ENOX2 is connected to other proteins implicated in cancer such as HER2/neu playing a role in breast cancer. Additionally it relates to neurodegenerative disorders where alterations in cellular metabolism contribute to disease progression although the precise mechanisms remain under investigation.

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製品の性状

製品の状態

Liquid

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一般的な情報

機能

May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.

配列の類似性

Belongs to the ENOX family.

翻訳後修飾

Glycosylated.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information ENOX2

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Abcam product promise

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Recombinant Human ENOX2/tNOX protein (Tagged)