Recombinant Human EDAR protein (denatured) (ab187467)
Key features and details
- Expression system: Escherichia coli
- Purity: > 85% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Recombinant Human EDAR protein (denatured)
EDAR タンパク質・ペプチド 製品一覧 -
精製度
> 85 % SDS-PAGE.
ab187467 is purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20 mM Tris pH 7.5, 2 mM EDTA. -
発現系
Escherichia coli -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
MGSSHHHHHHSSGLVPRGSHMGSEYSNCGENEYYNQTTGLCQECPPCGPG EEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLT PGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATS GASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIV LIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKD EFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLL SLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCL EKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRIST AGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS -
予測される分子量
48 kDa including tags -
領域
27 to 448 -
タグ
His tag N-Terminus -
配列の追加情報
Mature form. NCBI Accession No. NP_071731
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製品の詳細
Recombinant Human EDAR protein
関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab187467 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl
関連情報
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別名
- Anhidrotic ectodysplasin receptor 1
- DL
- Downless (mouse) homolog
see all -
機能
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. -
組織特異性
Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines. -
関連疾患
Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3) [MIM:129490]; also known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands. -
配列類似性
Contains 1 death domain.
Contains 3 TNFR-Cys repeats. -
発生段階
Found in craniofacial tissues from embryonic day 42-53. Expressed in fetal skin 11 and 15 weeks after gestation. -
細胞内局在
Membrane. - Information by UniProt
画像
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SDS-PAGE - Recombinant Human EDAR protein (denatured) (ab187467)
15% SDS-PAGE analysis of ab187467 (3μg).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab187467 は論文での使用が確認できていません。