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AB109940

Recombinant Human DRG1 protein

Recombinant Human DRG1 protein

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Recombinant Human DRG1 protein is a Human Full Length protein, in the 1 to 367 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

NEDD3, DRG1, Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, Translation factor GTPase DRG1, NEDD-3, TRAFAC GTPase DRG1

1 Images
SDS-PAGE - Recombinant Human DRG1 protein (AB109940)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human DRG1 protein (AB109940)

15% SDS-PAGE analysis of 3μg ab109940.

Key facts

精製度

>85% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

Mass Spec, SDS-PAGE

applications

生物活性

No

アクセッション番号

Q9Y295

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMSSTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK","proteinLength":"Full Length","predictedMolecularWeight":"42.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":367,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y295","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存温度
-20°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The DRG1 protein also known as Developmentally Regulated GTP-binding protein 1 is an important player in cellular functions. This highly conserved protein has a mass of approximately 42 kDa and is expressed in various tissues including the brain and testis indicating its essential role in different biological processes. It contains GTP-binding motifs important for its activity which allows the protein to interact with other molecular partners in the cell facilitating its participation in cellular events.
Biological function summary

DRG1 engages in several critical cellular processes beyond its mechanical functions. One of its notable roles involves contributions to ribosome biogenesis although it does not form a permanent complex with the ribosome. The protein supports cellular growth and division highlighting its potential in affecting cell cycle regulation. DRG1 associates transiently with other proteins allowing it to influence a range of biological functions including cellular growth signaling pathways.

Pathways

Research indicates that DRG1 links to important regulatory networks such as the Ras signaling and translational control pathways. Within these pathways DRG1 interacts with proteins like eukaryotic initiation factors which are important for translation regulation. This interaction plays a role in coordinating protein synthesis which supports overall cellular growth and response to environmental cues. Understanding its place in these pathways sheds light on how cells control protein production and growth.

Studies suggest DRG1's involvement in cancer and neurological disorders. In certain cancers altered expression of DRG1 correlates with tumor progression implicating its role in cell proliferation and survival mechanisms. Additionally DRG1 has connections to neurodegenerative disorders potentially through interactions with tau protein which is associated with abnormal protein deposits in the brain. The protein’s link to these diseases highlights the need for further research into its functional mechanisms and potential as a therapeutic target.
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製品の性状

製品の状態

Liquid

補足情報

ab109940 was purified using conventional chromatography techniques.

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一般的な情報

機能

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed : 23711155, PubMed : 29915238, PubMed : 37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed : 23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed : 19819225, PubMed : 29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed : 28855639).

配列の類似性

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

翻訳後修飾

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.. Phosphorylated at Thr-100 by STK16.. Hydroxylated (with S stereochemistry) at C-3 of Lys-22 by JMJD7; this modification hinders trypsin-catalyzed proteolysis in vitro.. Polyubiquitinated; this modification induces proteolytic degradation and is impaired by interaction with ZC3H15.

細胞内局在性

Nucleus

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed : 23711155, PubMed : 29915238, PubMed : 37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed : 23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed : 19819225, PubMed : 29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed : 28855639).
See full target information DRG1
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