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AB153553

Recombinant Human DGAT2 protein (GST tag N-Terminus)

Recombinant Human DGAT2 protein (GST tag N-Terminus)

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Recombinant Human DGAT2 protein (GST tag N-Terminus) is a Human Fragment protein, in the 289 to 388 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

HMFN1045, UNQ738/PRO1433, DGAT2, Diacylglycerol O-acyltransferase 2, Acyl-CoA retinol O-fatty-acyltransferase, Diglyceride acyltransferase 2, ARAT, Retinol O-fatty-acyltransferase

1 Images
SDS-PAGE - Recombinant Human DGAT2 protein (GST tag N-Terminus) (AB153553)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human DGAT2 protein (GST tag N-Terminus) (AB153553)

ab153553 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

WB, ELISA

applications

生物活性

No

アクセッション番号

Q96PD7

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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組合せ製品

Primary Antibodies

AB237613

Anti-DGAT2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DGAT2 antibody (AB237613)

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Proteins & Peptides

AB51301

Recombinant Human CEBP Alpha/CEBPA protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human CEBP Alpha/CEBPA protein (His tag N-Terminus) (AB51301)

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Primary Antibodies

AB181180

Anti-DGAT1 antibody [EPR13430-4] - N-terminal

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-DGAT1 antibody [EPR13430-4] - N-terminal (AB181180)

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Primary Antibodies

AB207799

Anti-Adipose Triglyceride Lipase antibody [EPR19650]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adipose Triglyceride Lipase antibody [EPR19650] (AB207799)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"IFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":388,"aminoAcidStart":289,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96PD7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Proprietary technique
出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The diacylglycerol O-acyltransferase 2 commonly referred to as DGAT2 plays a mechanical role in triglyceride biosynthesis by catalyzing the final step of triacylglycerol formation from diacylglycerol and acyl-CoA. This protein also functions under the name acyl-CoA:diacylglycerol acyltransferase 2. DGAT2 has a molecular weight of approximately 40-45 kDa. The enzyme is mainly expressed in tissues like the liver adipose tissue and intestines where lipid metabolism is an important function.
Biological function summary

DGAT2 significantly contributes to energy storage and lipid homeostasis in cells. The protein is not usually known to be part of a larger macromolecular complex but it works in association with lipid droplets where the fats are stored. The enzyme's activity significantly impacts the regulation of intracellular triglyceride levels making it important for maintaining energy balance within the cell and the entire organism.

Pathways

The role of DGAT2 is mainly tied to lipid metabolism particularly the triglyceride synthesis pathway. It directly assists in converting excess carbohydrates and other substrates into triglycerides for energy storage. DGAT2 works closely with proteins like DGAT1 another isoform involved in triacylglycerol synthesis and both contribute to maintaining adequate lipid storage and energy regulation within the body.

DGAT2 has implications in metabolic diseases such as obesity and non-alcoholic fatty liver disease (NAFLD). An overexpression or increased activity of DGAT2 can lead to excessive lipid formation and storage contributing to these conditions. It shows interaction with proteins like perilipin which are involved in lipid droplet formation influencing pathological fat accumulation in tissues. Low levels or activity of DGAT2 have also been investigated concerning insulin resistance further linking it to metabolic syndrome-related disorders.
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一般的な情報

機能

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed : 27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed : 28420705).

配列の類似性

Belongs to the diacylglycerol acyltransferase family.

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製品プロトコール

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ターゲットの情報

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed : 27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed : 28420705).
See full target information DGAT2
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