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Recombinant Human Cytochrome P450 17A1/CYP17A1 protein (ab152320)

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SDS-PAGE - Recombinant Human Cytochrome P450 17A1/CYP17A1 protein (ab152320)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: ELISA, WB, SDS-PAGE

    製品の詳細

    • 製品名

      Recombinant Human Cytochrome P450 17A1/CYP17A1 protein

    • 発現系

      Wheat germ

    • アクセッション番号

      P05093

    • タンパク質長

      Full length protein

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMH NNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMA TLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEI STLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQN YNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENY KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRL LLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALH HNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ ELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWR EAQAEGST

      • 予測される分子量

        82 kDa including tags

      • 領域

        1 to 508

    特性

    Our Abpromise guarantee covers the use of ab152320 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      ELISA

      Western blot

      SDS-PAGE

    • 製品の状態

      Liquid

    • 備考

      This product was previously labelled as Cytochrome P450 17A1.

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    関連情報

    • 別名

      • 20 lyase
      • CP17A_HUMAN
      • CPT7
      • CYP17
      • CYP17A1
      • CYPXVII
      • Cytochrome P450 17A1
      • Cytochrome P450 family 17
      • Cytochrome P450 family 17 subfamily A polypeptide 1
      • Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia
      • Cytochrome p450 XVIIA1
      • Cytochrome P450-C17
      • Cytochrome P450c17
      • OTTHUMP00000020382
      • P450 C17
      • P450c17
      • S17AH
      • Steroid 17 alpha hydroxylase/17,20 lyase
      • Steroid 17 alpha monooxygenase
      • Steroid 17-alpha-hydroxylase/17
      • Steroid 17-alpha-monooxygenase
      see all

    • 機能

      Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

    • パスウェイ

      Lipid metabolism; steroid biosynthesis.

    • 関連疾患

      Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic).

    • 配列類似性

      Belongs to the cytochrome P450 family.

    • 翻訳後修飾

      Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.

    • 細胞内局在

      Membrane.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human Cytochrome P450 17A1/CYP17A1 protein (ab152320)
      SDS-PAGE - Recombinant Human Cytochrome P450 17A1/CYP17A1 protein (ab152320)
      12.5% SDS-PAGE analysis of ab152320 stained with Coomassie Blue.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab152320 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab152320 は論文での使用が確認できていません。

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