AB119719

Recombinant Human Cyclin E1 protein

Name: Recombinant Human Cyclin E1 protein (ab119719) | Abcam
Brand: Abcam Limited
SKU: AB119719
Price: 68000 JPY
Availability: InStock

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(1 Publication)

Recombinant Human Cyclin E1 protein is a Human Full Length protein, in the 1 to 410 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, WB.

別名を表示する

CCNE, CCNE1, G1/S-specific cyclin-E1

1 Images

SDS-PAGE - Recombinant Human Cyclin E1 protein (AB119719)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Cyclin E1 protein (AB119719)

SDS Page analysis of ab119719

Key facts

精製度

>90% SDS-PAGE

発現系

Baculovirus infected Sf9 cells

アプリケーション

WB, SDS-PAGE

applications

生物活性

アクセッション番号

P24864

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.003% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"73 kDa","actualMolecularWeight":null,"aminoAcidEnd":410,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P24864","tags":[]}]

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出荷温度及び保存条件

出荷温度

Dry Ice

短期保存温度

-80°C

長期保存温度

-80°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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製品の性状

製品の状態

Liquid

補足情報

Purity tested by densitometry. Affinity purified.

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一般的な情報

機能

Essential for the control of the cell cycle at the G1/S (start) transition.

配列の類似性

Belongs to the cyclin family. Cyclin E subfamily.

翻訳後修飾

Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.. Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.

細胞内局在性

Nucleus

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Essential for the control of the cell cycle at the G1/S (start) transition.

See full target information CCNE1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Science advances 9:eadi3821 PubMed37801505

2023

LncRNA EILA promotes CDK4/6 inhibitor resistance in breast cancer by stabilizing cyclin E1 protein.

Applications

Unspecified application

Species

Unspecified reactive species

Zijie Cai,Qianfeng Shi,Yudong Li,Liang Jin,Shunying Li,Lok Lam Wong,Jingru Wang,Xiaoting Jiang,Mengdi Zhu,Jinna Lin,Qi Wang,Wang Yang,Yujie Liu,Jun Zhang,Chang Gong,Herui Yao,Yandan Yao,Qiang Liu

View all publications

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Abcam product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Recombinant Human Cyclin E1 protein