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AB314630

Recombinant Human CNGA4 Protein (His Tag)

Recombinant Human CNGA4 Protein (His Tag)

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Recombinant Human CNGA4 Protein (His Tag) is a Human Full Length protein, in the 1 to 575 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

別名を表示する

Cyclic nucleotide-gated channel alpha-4, CNG channel alpha-4, CNGa4, Olfactory cyclic nucleotide-gated channel subunit 2, OCNC2, CNGA4

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SDS-PAGE - Recombinant Human CNGA4 Protein (His Tag) (AB314630)
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Supplier Data

SDS-PAGE - Recombinant Human CNGA4 Protein (His Tag) (AB314630)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. The difference between the theoretical value and the observed value may be related to the molecular structure of the protein. It is predicted that the isoelectric point pI of the fusion protein is 5.39, the acidic protein usually shows higher molecular weight when runs on the gel. There is also evidence of alternative splicing of the protein, and alternative splicing can produce proteins of different sizes from the same gene.

Key facts

精製度

>85% SDS-PAGE

発現系

Escherichia coli

タグ

6x His tag N-Terminus SUMO tag N-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

Q8IV77

アニマルフリー

Yes

キャリアフリー

No

種

Human

再構成

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

バッファー組成

pH: 7.4 - 8 Constituents: PBS, 6% Trehalose

storage-buffer

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組合せ製品

Proteins & Peptides

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"MSQDTKVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWPMPEDLAEADDEGEPEEGTSKDEEGRASQEGPPGPE","proteinLength":"Full Length","predictedMolecularWeight":"82 kDa","actualMolecularWeight":null,"aminoAcidEnd":575,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8IV77","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Lyophilized
精製方法
Ion exchange chromatography
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-80°C
分注に関する情報
Add glycerol to a final volume of 50% for extra stability and aliquot
保管に関する情報
The product can be stored for up to 12 months
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一般的な情報

機能

Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations.

配列の類似性

Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily.

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製品プロトコール

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ターゲットの情報

Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations.
See full target information Human Cyclic nucleotide-gated cation channel alpha-4
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