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AB198642

Recombinant Human CHD2 protein (GST tag N-Terminus)

Recombinant Human CHD2 protein (GST tag N-Terminus)

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Recombinant Human CHD2 protein (GST tag N-Terminus) is a Human Fragment protein, in the 260 to 456 aa range, expressed in Escherichia coli, with >82%, suitable for SDS-PAGE.

別名を表示する

Chromodomain-helicase-DNA-binding protein 2, CHD-2, ATP-dependent helicase CHD2, CHD2

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SDS-PAGE - Recombinant Human CHD2 protein (GST tag N-Terminus) (AB198642)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CHD2 protein (GST tag N-Terminus) (AB198642)

4-20% SDS-PAGE with Coomassie staining.

Lane 1 : 2 μg ab198642
Lane 2 : Protein marker

Key facts

精製度

>82% SDS-PAGE

発現系

Escherichia coli

タグ

GST tag N-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

O14647

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.017% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQGPLGSSETIEKVLDSRLGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDVEYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNSKTIPTR","proteinLength":"Fragment","predictedMolecularWeight":"49.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":456,"aminoAcidStart":260,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O14647","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The CHD2 protein also known as Chromodomain-Helicase-DNA-binding protein 2 acts as an ATP-dependent chromatin remodeler. This protein has a mass of approximately 210 kDa. CHD2 is expressed in various tissues with higher expression levels noted in the brain and skeletal muscle. As a part of the chromatin remodeling family CHD2 plays a role in modifying the structure of chromatin to affect gene expression.
Biological function summary

CHD2 contributes to DNA repair and transcription regulation by modifying chromatin structure. It is a part of the CHD family of chromatin remodelers which influences nucleosome positioning and accessibility. By facilitating transcription CHD2 impacts gene expression necessary for neural development and other processes. CHD2 functions as a monomer and does not form larger protein complexes.

Pathways

CHD2 influences gene expression regulation and neural development. It plays a role in the transcriptional regulation pathway by interacting with chromatin to control the accessibility of transcription factors. The protein links with others like CHD3 and CHD4 within this pathway to coordinate chromatin conformation changes necessary for proper transcription processes.

The CHD2 protein relates to epileptic encephalopathy and neurodevelopmental disorders. Mutations in the CHD2 gene associate with these conditions affecting neurological function and development. CHD2 mutations often coexist with other genetic factors involving proteins like SCN1A contributing to the complex nature of these disorders.
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製品の性状

製品の状態

Liquid

補足情報

Lot specific

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一般的な情報

機能

DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1 : binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).

配列の類似性

Belongs to the SNF2/RAD54 helicase family.

細胞内局在性

Nucleus

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製品プロトコール

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ターゲットの情報

DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1 : binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).
See full target information CHD2
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組合せ製品

Primary Antibodies

AB167377

Anti-CHD2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CHD2 antibody (AB167377)

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Proteins & Peptides

AB95933

Recombinant human XIAP protein (DDDDK tag N-Terminus)

Functional Studies - Recombinant human XIAP protein (DDDDK tag N-Terminus) (AB95933)

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Proteins & Peptides

AB313361

Recombinant Human WFDC2 Protein (His tag)

Mass Spectrometry - Recombinant Human WFDC2 Protein (His tag) (AB313361)

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Proteins & Peptides

AB217407

Recombinant human Vitronectin/S-Protein (Animal Free)

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