JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB196137

Recombinant Human CECR2 protein (GST tag N-Terminus)

Recombinant Human CECR2 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human CECR2 protein (GST tag N-Terminus) is a Human Fragment protein, in the 430 to 543 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

別名を表示する

KIAA1740, CECR2, Chromatin remodeling regulator CECR2, Cat eye syndrome critical region protein 2

1 Images
SDS-PAGE - Recombinant Human CECR2 protein (GST tag N-Terminus) (AB196137)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CECR2 protein (GST tag N-Terminus) (AB196137)

4-20% SDS-PAGE analysis of 3 μg ab196137 with Coomassie staining.

Key facts

精製度

>90% SDS-PAGE

発現系

Escherichia coli

タグ

GST tag N-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

Q9BXF3

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

配列情報

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQGPLGSTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKHFPGED","proteinLength":"Fragment","predictedMolecularWeight":"40.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":543,"aminoAcidStart":430,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BXF3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
保管に関する情報
Avoid freeze / thaw cycle
False
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The CECR2 protein also known as Cat Eye Syndrome Chromosome Region Candidate 2 plays an important role in chromatin remodeling. It has a molecular mass of approximately 150 kDa. This protein functions as part of the CECR2-containing complex (CERF) which takes part in the regulation of nucleosome catalysis. CECR2 expresses in various tissues with notable expression in the testis brain and fetal tissue.
Biological function summary

The CECR2 protein engages in modulating transcriptional activity influencing the accessibility of DNA for transcription machinery. It acts as a component of the CERF complex integrating with multiple other proteins to facilitate these transcriptional adjustments. This action directly affects gene expression patterns critical for developmental processes particularly in neurogenesis and spermatogenesis.

Pathways

CECR2 interacts in the chromatin remodeling pathways essential for DNA replication and repair. The protein associates with SWI/SNF-like chromatin-remodeling complexes. These complexes enhance the efficient binding of transcriptional factors such as those of the BRG1/BRM-associated factor (BAF) complex. This interaction supports regulatory processes in embryonic development and cellular differentiation.

CECR2 mutations or dysregulation have strong links to neural tube defects and Cat Eye Syndrome. Neural tube defects result from improper closure of the neural tube during early embryonic development where CECR2 plays a regulatory role. The protein also relates to conditions involving altered chromatin structure. CECR2's relationship with other proteins involved in neural tube closure disorders like SHH (Sonic Hedgehog) highlights its relevance in these pathologies.
style
left-column

製品の性状

製品の状態

Liquid

style
left-column

一般的な情報

機能

Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed : 15640247, PubMed : 22464331, PubMed : 26365797, PubMed : 28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed : 28801535). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (PubMed : 28801535). Plays a role in various processes during development : required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones : binds histones that are acetylated and/or butyrylated (PubMed : 22464331, PubMed : 26365797). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed : 11827465).

style
left-column

製品プロトコール

style
left-column

ターゲットの情報

Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed : 15640247, PubMed : 22464331, PubMed : 26365797, PubMed : 28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed : 28801535). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (PubMed : 28801535). Plays a role in various processes during development : required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones : binds histones that are acetylated and/or butyrylated (PubMed : 22464331, PubMed : 26365797). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed : 11827465).
See full target information CECR2
style
left-column
style
left-column
style
right-column

組合せ製品

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB313361

Recombinant Human WFDC2 Protein (His tag)

Mass Spectrometry - Recombinant Human WFDC2 Protein (His tag) (AB313361)

  • 0
  • 0
Proteins & Peptides

AB217407

Recombinant human Vitronectin/S-Protein (Animal Free)

  • 0
  • 0
Proteins & Peptides

AB95933

Recombinant human XIAP protein (DDDDK tag N-Terminus)

Functional Studies - Recombinant human XIAP protein (DDDDK tag N-Terminus) (AB95933)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com